Project Summary:
The microbiome, composed of billions of microorganisms that reside in the gut, can have both beneficial and detrimental effects on human health. One way it influences health is by metabolizing foods and other molecules into compounds known as ‘postbiotics’. Dr. Mine found that a particular postbiotic, isoLCA, has an immunomodulatory effect. He found that isoLCA reduces levels of a pro-inflammatory molecule that promotes the activation of inflammatory immune cells. Since these inflammatory immune cells are responsible for T1D, Dr. Mine hypothesizes that treatment isoLCA could prevent the inflammatory immune cells from being activated, therefore, preventing the onset of T1D. Dr. Mine’s will assess the therapeutic potential of isoLCA to reduce immune cell activation and prevent the development of T1D.
