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Project Description
Our project aims to delve into how type 1 diabetes (T1D) impacts the beta cells responsible for producing insulin in your body. Traditionally, it was believed that the immune system alone attacked these beta cells, causing damage. However, recent research hints that beta cells might play a role in their own demise.
We’re particularly intrigued by a cellular process called autophagy, likened to a cleanup crew within cells. It’s essential for clearing out old or damaged parts to maintain cell health. Our study zeroes in on how autophagy functions in beta cells and how it might be disrupted in T1D. Specifically, we’re interested in a component of autophagy called lysosomal function, akin to a recycling center in cells. We’re investigating whether issues with lysosomal function contribute to beta cell damage and, consequently, insulin production problems in T1D.
To explore this, we’re utilizing cutting-edge imaging techniques to observe these processes in real-time, both in lab-grown cells and in live mice. By developing tools to track lysosomal pH levels and using beta cell-specific sensors, we aim to uncover fresh insights into the development and progression of T1D. Additionally, we’re testing various drugs to see if we can restore lysosomal function and bolster the health of beta cells.
Through a deeper understanding of these cellular mechanisms, we aspire to discover novel ways to shield beta cells and impede the progression of T1D. Your support for our research not only aids in unraveling the mysteries of T1D but also lays the groundwork for improved therapies in the future.
