Our Projects

See our approved research projects and campaigns.

Many exciting projects simply couldn’t get off the ground. Until now.

Choose one or more projects you want to support. 100% of your donation, directed to a research project, will go to that scientist’s laboratory.

Research Projects

Role of the integrated stress response in type 1 diabetes pathogenesis
In individuals with type 1 diabetes (T1D), the insulin-producing beta cells are spontaneously destroyed by their own immune system. The trigger that provokes the immune system to destroy the beta cells is unknown. However, accumulating evidence suggest that signals are perhaps first sent out by the stressed beta cells that eventually attracts the immune cells. Stressed cells adapt different stress mitigation systems as an adaptive response. However, when these adaptive responses go awry, it results in cell death. One of the stress response mechanisms, namely the integrated stress response (ISR) is activated under a variety of stressful stimuli to promote cell survival. However, when ISR is chronically activated, it can be damaging to the cells and can lead to cell death. The role of the ISR in the context of T1D is unknown. Therefore, in this DRC funded study, we propose to study the ISR in the beta cells to determine its role in propagating T1D.
Wearable Skin Fluorescence Imaging Patch for the Detection of Blood Glucose Level on an Engineered Skin Platform
zhang
A Potential Second Cure for T1D by Re-Educating the Patient’s Immune System
L Ferreira
Validating the Hypothesis to Cure T1D by Eliminating the Rejection of Cells From Another Person by Farming Beta Cells From a Patient’s Own Stem Cells
Han Zhu
Taming a Particularly Lethal Category of Cells May Reduce/Eliminate the Onset of T1D
JRDwyer 2022 Lab 1
Can the Inhibition of One Specific Body Gene Prevent Type 1 Diabetes?
Melanie
Is Cholesterol Exacerbating T1D by Reducing the Functionality and Regeneration Ability of Residual Beta Cells?
Regeneration Ability of Residual Beta Cells
A Call to Question… Is T1D Caused by Dysfunctionality of Two Pancreatic Cells (β and α)?
Xin Tong
Novel therapy initiative with potential path to preventing T1D by targeting TWO components of T1D development (autoimmune response and beta-cell survival)
flavia pecanha

Successfully Funded

A New Signal to Halting T1D
Dr. Hughes
Bionic Insulin Pump – Tarson Family Project
Diabetes Researching
What Type of Type 1 Diabetes Do You Have?
Jane Kim
Mice to Men
YongKyung Kim
Engineering an Insulin/Glucagon Fusion Protein
Balamurugan Dhayalan, Ph.D.
Engineering Immune Cells To Stop Autoimmune Attacks
Todd Brusko
A Bacteria in the Gut May Predict Type 1 Diabetes
Youjia Hu Headshot
Preventing and Possibly Curing T1D by Blocking the Autoimmune Attack of Pancreatic Beta Cells
Michael Kalwat
Cell Silence can be Golden to Improving the Cure for T1D
Dr. Meier
What is the Connection Between T1D and Depression?
Agata-Headshot
Creating New Insulin-Producing Cells To Repair Damaged Pancreas
Kristin-Mussar in a labcoat
Do Classical T1D Patients Share Genetic Makeup with ICI-Induced T1D Patients?
Jeremy Racine
Gene-Specific Models and Therapies for Type One Diabetes
Will understanding why normally good but aging beta-cells accumulate with the progression of T1D unlock the mystery of this disease?
Yao Wang
Looking Beyond Beta-Cells for Management of T1D
Diabetes Cell Management
Making More And Better Insulin Producing Cells With Cell Regeneration
Snageeta
Needles be Gone for Type One Diabetes Patients
Yo Suzuki
A New Approach to Disrupting the Onset of T1D
  • View Project
  • Almost there. Please help fund this project today!
Diabetes Researching
Almost there. Please help fund this project today!
A New Approach To Retraining Immunity In Patients With T1D
Daniel Moore
Novel Engraftment Strategies for a Bioengineered Pancreas in the Treatment of Type 1 Diabetes
NOVEL ENGRAFTMENT STRATEGIES
A Novel Stem Cell Approach for Curing Diabetes
Wendy
Offensive “Blocking” to Defeat T1D Before it Strikes!
Marika Bogdani lab photo
Preserving Retinal Cells Survival and Function for Potential Clinical Studies in T1D
Diabetes Research
Advancing T1 Prevention and Cure Solutions from Cancer Research
Zoe Quandt
Regrowth of Beta Cells with Small Molecule Therapy
Replacement Beta-Cells From An Unexpected Source
Dr.Lancman in Lab
Reversing Type 1 Diabetes Without Insulin Replacement
Gunawardana
Scripps Digital Diabetes: Glucose Values As A Vital Sign
Addie
Improving Islet Transplantation Treatment by Overcoming a Critical Roadblock for Beta-Cell Survival via Synthetic Gene Circuits that Generate “Self-Healing” Beta Cells
Ashe
Skeletal Muscle Health and Blood Sugar Control In Type 1 Diabetes
PGB
Step 1 in a New Strategy to Preserve Insulin Secretion in People with T1D
FV and AB
Taking out the Trash: Clearance of Sick Human Beta-Cells for the Prevention of Type 1 Diabetes. – Tarson Family Project
Dr Arora
Targeting Polyamine Biosynthesis for the Prevention of T1D
Abhishek Kulkarni
Using Autonomous Artificial Intelligence (AI) to Improve Early Detection of Diabetic Retinopathy in Children with T1D
Wolf - Diabetic Retinopathy
Combination Insulin and Non-Insulin Therapy to Address Multiple Metabolic Abnormalities in Type 1 Diabetes
Schafer Boeder
Deciphering Maternal Type 1 Diabetes-Induced Embryonic Defects
Basu
Stakeholder-Engaged Precision Health for Longevity and Healthy Aging with Type 1 Diabetes (T1D)
Kahkoska Headshot
Understanding How a Pancreatic Molecule (GABA) Works May Lead to a New Treatment for T1 and T2 Diabetes
Sandra Mara F.

Diabetes Research Team

Why Should You Donate

100% of your donation for a research project goes directly to the scientists.

Currently 1.25 million Americans live with type 1 diabetes (T1D), including 200,000 children. Approximately 40,000 new patients are diagnosed yearly. Despite this, funding has decreased for research to prevent, cure, and better manage the disease. What diabetes funding is available generally goes to established scientists.

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