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Building a pipeline of researchers

Building a Pipeline of Young Researchers

New and innovative research is essential to continuing to expand scientific knowledge and improve the future of healthcare. Yet over the years, the biomedical community has seen a troubling downward trend in funding, support, and opportunities for young researchers. A study published in the Proceedings of the National Academy of Sciences of the United States of America investigated some potential factors for why investigators are struggling early on in their careers and not receiving as much funding to stimulate independent research.

For years, attaining an R01 from the National Institutes of Health (NIH) has been a prerequisite for young biomedical researchers to become independent investigators and start their own laboratories. Yet the average age that they receive their first R01 has steadily increased from less than 38 years old in 1980 to more than 45 years old in 2013. In 1980, 5.6% of grant funding went to investigators who were younger than 36, but by 2012, this had dropped to just 1.3%. Principal investigators over age 65 are awarded more than twice as many R01s as those under age 36.

It has become increasingly challenging for young scientists to secure necessary funds to advance their careers in research. In turn, this puts future generations of biomedical researchers in jeopardy because more scientists are becoming disheartened and exploring other career paths. It also disrupts the emergence of scientific breakthroughs from bright young minds with untapped potential.

There are many reasons why young investigators may be losing out on the fight for NIH funding. For one, some are spending more time in post-doctoral programs training and it is taking longer for them to secure faculty positions. There may also be unintentional bias from review committees to select more established investigators who have a proven track record of success rather than taking a risk on unknown scientists. Funding has been reduced over the years making the competition fiercer and the awarding of grants increasingly selective. This also means that universities must shoulder a larger portion of the costs associated with supporting research endeavors.

The Diabetes Research Connection (DRC) is reversing this trend by funding early-career scientists who then leverage funding from DRC to seek additional funding from larger foundations and NIH.


DRC is supporting the next generation by directing its fundraising toward early-career scientists. It recognizes that mainstream funding is highly competitive, and, as the above research has shown, is less frequently awarded to young researchers. Through DRC, scientists receive up to $70,000 from donors for their research projects, which can be enough to give them a strong foundation to conduct novel research related to type 1 diabetes. To learn more about current projects and support these efforts, visit http://diabetesresearchconnection.org.

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See our approved research projects and campaigns.

Role of the integrated stress response in type 1 diabetes pathogenesis
In individuals with type 1 diabetes (T1D), the insulin-producing beta cells are spontaneously destroyed by their own immune system. The trigger that provokes the immune system to destroy the beta cells is unknown. However, accumulating evidence suggest that signals are perhaps first sent out by the stressed beta cells that eventually attracts the immune cells. Stressed cells adapt different stress mitigation systems as an adaptive response. However, when these adaptive responses go awry, it results in cell death. One of the stress response mechanisms, namely the integrated stress response (ISR) is activated under a variety of stressful stimuli to promote cell survival. However, when ISR is chronically activated, it can be damaging to the cells and can lead to cell death. The role of the ISR in the context of T1D is unknown. Therefore, in this DRC funded study, we propose to study the ISR in the beta cells to determine its role in propagating T1D.
Wearable Skin Fluorescence Imaging Patch for the Detection of Blood Glucose Level on an Engineered Skin Platform
A Potential Second Cure for T1D by Re-Educating the Patient’s Immune System
L Ferreira
Validating the Hypothesis to Cure T1D by Eliminating the Rejection of Cells From Another Person by Farming Beta Cells From a Patient’s Own Stem Cells
Han Zhu
Taming a Particularly Lethal Category of Cells May Reduce/Eliminate the Onset of T1D
JRDwyer 2022 Lab 1
Can the Inhibition of One Specific Body Gene Prevent Type 1 Diabetes?
Is Cholesterol Exacerbating T1D by Reducing the Functionality and Regeneration Ability of Residual Beta Cells?
Regeneration Ability of Residual Beta Cells
A Call to Question… Is T1D Caused by Dysfunctionality of Two Pancreatic Cells (β and α)?
Xin Tong
Novel therapy initiative with potential path to preventing T1D by targeting TWO components of T1D development (autoimmune response and beta-cell survival)
flavia pecanha