DRC & Research News

This page shares the latest news in T1D research and DRC’s community.

Get the most recent diabetes research news, delivered straight to your inbox


Key Control Factor in Regulating Blood Glucose Level Identified

Despite years of research, type 1 diabetes remains a complex disease without a definitive cure. However, researchers continue to make new discoveries in how the disease develops and impacts the body. This allows for more targeted approaches to treatment. One such recent discovery is pinpointing the mechanism that is believed to be primarily responsible for controlling blood glucose levels in humans.

Researchers at the Karolinska Institutet in Sweden and the University of Miami Miller School of Medicine in Florida have released a study that identifies pancreatic islets as the main control function. Though glucose homeostasis involves the liver, hypothalamus, and pancreas, it is the pancreatic islets which release hormones and insulin that appear to have the most influence in regulation.

Different animals have their own set point of what is a normal blood glucose range, including humans. The researchers transplanted pancreatic islets from different animals into mice with and without diabetes. According to Principal Investigator Per-Olof Berggren, a professor at the Rolf Luft Research Centre for Diabetes and Endocrinology at Karolinska Institutet’s Department of Molecular Medicine and Surgery, “We found that the engrafted islets transferred the glycemic levels of the donor species. This indicates that the pancreatic islets have the overall responsibility for maintaining normal blood glucose levels, making them the ‘glucostat’ in our bodies.”

Human pancreatic islets contain cells that release the hormone glucagon which regulates insulin-producing cells. This is an important discovery when it comes to developing treatment approaches because scientists may find that including these hormone-producing cells in addition to insulin-producing cells when creating artificial islets could be beneficial in better-regulating blood glucose levels.

It is these types of discoveries that enable researchers to develop more advanced and effective options for treating and potentially curing type 1 diabetes. The Diabetes Research Connection supports early career scientists in pursuing novel research projects aimed at diagnosing and treating type 1 diabetes as well as improving quality of life for individuals living with the disease. To learn more about their innovative research and contribute to its advancement, visit http://diabetesresearchconnection.org.

Learn More +


See our approved research projects and campaigns.

Role of the integrated stress response in type 1 diabetes pathogenesis
In individuals with type 1 diabetes (T1D), the insulin-producing beta cells are spontaneously destroyed by their own immune system. The trigger that provokes the immune system to destroy the beta cells is unknown. However, accumulating evidence suggest that signals are perhaps first sent out by the stressed beta cells that eventually attracts the immune cells. Stressed cells adapt different stress mitigation systems as an adaptive response. However, when these adaptive responses go awry, it results in cell death. One of the stress response mechanisms, namely the integrated stress response (ISR) is activated under a variety of stressful stimuli to promote cell survival. However, when ISR is chronically activated, it can be damaging to the cells and can lead to cell death. The role of the ISR in the context of T1D is unknown. Therefore, in this DRC funded study, we propose to study the ISR in the beta cells to determine its role in propagating T1D.
Wearable Skin Fluorescence Imaging Patch for the Detection of Blood Glucose Level on an Engineered Skin Platform
A Potential Second Cure for T1D by Re-Educating the Patient’s Immune System
L Ferreira
Validating the Hypothesis to Cure T1D by Eliminating the Rejection of Cells From Another Person by Farming Beta Cells From a Patient’s Own Stem Cells
Han Zhu
Taming a Particularly Lethal Category of Cells May Reduce/Eliminate the Onset of T1D
JRDwyer 2022 Lab 1
Can the Inhibition of One Specific Body Gene Prevent Type 1 Diabetes?
Is Cholesterol Exacerbating T1D by Reducing the Functionality and Regeneration Ability of Residual Beta Cells?
Regeneration Ability of Residual Beta Cells
A Call to Question… Is T1D Caused by Dysfunctionality of Two Pancreatic Cells (β and α)?
Xin Tong
Novel therapy initiative with potential path to preventing T1D by targeting TWO components of T1D development (autoimmune response and beta-cell survival)
flavia pecanha