DRC & Research News

This page shares the latest news in T1D research and DRC’s community.

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Protecting Pancreatic Islet Cells Following Transplantation for T1D

One of the challenges researchers have faced in developing long-term treatment options for type 1 diabetes (T1D) using allogeneic cells is that the body often rejects these cells. This means that patients would still need to take anti-rejection or immunosuppressant medications, which can be hard on the body and contribute to other issues. However, researchers may have found an option that protects cells while allowing them to control glucose levels.

In a new study, researchers encapsulated pancreatic islet cells with seven different alginate formulations and transplanted them into non-human primates. The goal was to maintain function of the cells without disruption by common challenges such as foreign-body response, pericapsular fibrotic overgrowth, or sedimentation of the microspheres. Of the seven alginates used, three showed transient islet graft function with decreased foreign-body response. One of the chemically modified microsphere formulations protected cells and glucose-response for four months without requiring immunosuppression.

This is a positive step toward correcting insulin deficiency using allogeneic cells. More research is necessary on the alginate formulations, and clinical trials have not yet been conducted in humans. The Diabetes Research Connection (DRC), though not involved in this trial, is interested to see where this study will lead and what it may mean for the future of T1D treatment options.

The DRC is committed to supporting T1D research and providing funding for early career scientists to carry out novel research projects. Learn more about current projects by visiting http://diabetesresearchconnection.org and consider donating to these efforts.

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OUR PROJECTS

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Role of the integrated stress response in type 1 diabetes pathogenesis
In individuals with type 1 diabetes (T1D), the insulin-producing beta cells are spontaneously destroyed by their own immune system. The trigger that provokes the immune system to destroy the beta cells is unknown. However, accumulating evidence suggest that signals are perhaps first sent out by the stressed beta cells that eventually attracts the immune cells. Stressed cells adapt different stress mitigation systems as an adaptive response. However, when these adaptive responses go awry, it results in cell death. One of the stress response mechanisms, namely the integrated stress response (ISR) is activated under a variety of stressful stimuli to promote cell survival. However, when ISR is chronically activated, it can be damaging to the cells and can lead to cell death. The role of the ISR in the context of T1D is unknown. Therefore, in this DRC funded study, we propose to study the ISR in the beta cells to determine its role in propagating T1D.
Wearable Skin Fluorescence Imaging Patch for the Detection of Blood Glucose Level on an Engineered Skin Platform
zhang
A Potential Second Cure for T1D by Re-Educating the Patient’s Immune System
L Ferreira
Validating the Hypothesis to Cure T1D by Eliminating the Rejection of Cells From Another Person by Farming Beta Cells From a Patient’s Own Stem Cells
Han Zhu
Taming a Particularly Lethal Category of Cells May Reduce/Eliminate the Onset of T1D
JRDwyer 2022 Lab 1
Can the Inhibition of One Specific Body Gene Prevent Type 1 Diabetes?
Melanie
Is Cholesterol Exacerbating T1D by Reducing the Functionality and Regeneration Ability of Residual Beta Cells?
Regeneration Ability of Residual Beta Cells
A Call to Question… Is T1D Caused by Dysfunctionality of Two Pancreatic Cells (β and α)?
Xin Tong
Novel therapy initiative with potential path to preventing T1D by targeting TWO components of T1D development (autoimmune response and beta-cell survival)
flavia pecanha