DRC & Research News

This page shares the latest news in T1D research and DRC’s community.

Get the most recent diabetes research news, delivered straight to your inbox

Low Blood Sugar

What You Need to Know About Hypoglycemia Unawareness

Many people are aware of warning signs that their blood sugar is too low. They experience sweating, shakiness, hunger, or dizziness. They may also feel confused, sleepy, or weak. As a result, they eat or drink something to bring their blood sugar back up. However, some people with diabetes are unaware of the signs of hypoglycemia or low blood sugar – not that they don’t know what the symptoms are, they just don’t experience or perceive them. This can be dangerous to their health and well-being.

There are numerous risk factors for hypoglycemia including:

  • Sleeping: Blood sugar may drop while sleeping and occur frequently enough that it alters their ability to detect symptoms while awake.
  • Time: The longer someone lives with diabetes, the less sensitive they may become to low blood sugar. People who have used insulin for 20 years or more tend to be at greater risk.
  • Age: Older adults may experience cognitive changes that affect their ability to recognize hypoglycemia.
  • Exercise: Rigorous exercise can affect blood sugar levels up to 15 hours later.
  • Alcohol: When the liver is occupied with processing alcohol, it may not be able to release glucose as effectively resulting in hypoglycemia.
  • Prescription Drugs: Certain medications may affect a person’s ability to recognize symptoms of low blood sugar.

However, there are several ways to manage hypoglycemia unawareness and be proactive in keeping blood sugar in check.

  • Testing blood sugar more frequently throughout the day can help individuals to recognize when their blood sugar is getting low so they can treat it early.
  • Using a continuous glucose monitoring system (CGM) or automatic insulin delivery (AID) device can help with tracking blood sugar trends and administering or suspending insulin as necessary. This can help to achieve more stable blood glucose levels and reduce incidences of hypoglycemia.
  • Using long-acting or fast-acting insulin analogs may help as well, especially at night and during meal times.
  • Targeted training on improved insulin usage and how to be proactive in managing blood sugar can reduce risk. Working with a certified diabetes educator can be very beneficial in managing hypoglycemia unawareness.

Effectively managing blood sugar is an essential part of living with type 1 diabetes, but that can be difficult, especially with so many contributing factors and the fact that every person is different. That is what makes the work of the Diabetes Research Connection (DRC) even more important. The DRC provides vital funding for early career scientists to pursue novel research projects geared toward diagnosing, treating, and curing type 1 diabetes, as well as improving quality of life for individuals living with the disease. Their studies have the potential to make a difference in the future of type 1 diabetes care. Find out more about current projects and how to support these efforts by visiting http://diabetesresearchconnection.org.

Learn More +


See our approved research projects and campaigns.

Role of the integrated stress response in type 1 diabetes pathogenesis
In individuals with type 1 diabetes (T1D), the insulin-producing beta cells are spontaneously destroyed by their own immune system. The trigger that provokes the immune system to destroy the beta cells is unknown. However, accumulating evidence suggest that signals are perhaps first sent out by the stressed beta cells that eventually attracts the immune cells. Stressed cells adapt different stress mitigation systems as an adaptive response. However, when these adaptive responses go awry, it results in cell death. One of the stress response mechanisms, namely the integrated stress response (ISR) is activated under a variety of stressful stimuli to promote cell survival. However, when ISR is chronically activated, it can be damaging to the cells and can lead to cell death. The role of the ISR in the context of T1D is unknown. Therefore, in this DRC funded study, we propose to study the ISR in the beta cells to determine its role in propagating T1D.
Wearable Skin Fluorescence Imaging Patch for the Detection of Blood Glucose Level on an Engineered Skin Platform
A Potential Second Cure for T1D by Re-Educating the Patient’s Immune System
L Ferreira
Validating the Hypothesis to Cure T1D by Eliminating the Rejection of Cells From Another Person by Farming Beta Cells From a Patient’s Own Stem Cells
Han Zhu
Taming a Particularly Lethal Category of Cells May Reduce/Eliminate the Onset of T1D
JRDwyer 2022 Lab 1
Can the Inhibition of One Specific Body Gene Prevent Type 1 Diabetes?
Is Cholesterol Exacerbating T1D by Reducing the Functionality and Regeneration Ability of Residual Beta Cells?
Regeneration Ability of Residual Beta Cells
A Call to Question… Is T1D Caused by Dysfunctionality of Two Pancreatic Cells (β and α)?
Xin Tong
Novel therapy initiative with potential path to preventing T1D by targeting TWO components of T1D development (autoimmune response and beta-cell survival)
flavia pecanha