DRC & Research News

This page shares the latest news in T1D research and DRC’s community.

Get the most recent diabetes research news, delivered straight to your inbox

david winkler

National Tell A Story Day: A Founder’s Story

At the age of six, I knew something wasn’t quite right. I didn’t have the same energy as all the other kids did that I played with. My mom took me to the doctor and after running a few tests, the doctor says to my mom and me, “David has Type 1 Diabetes and won’t live past the age of 30”. We were devasted. Trying to comprehend and make sense of what my diagnosis actually meant at age 6 was impossible. There were no support systems in place back then. Not for me and not for my family.

It was 1960 and the management of T1D was in the “Stone Age”. I remember having to sharpen my own needles at home with a grinding stone, so I could inject myself with animal insulin that gave me horrible welts, it was extremely painful. To monitor my blood sugar, my mom would drive me to the hospital once a quarter to test through a urine sample.

Today, my blood is tested 288 times a day through a monitor. Those needles that I had to sharpen myself, have been replaced with an insulin pen. And, I proved those doctor’s wrong, I’m now in my 60’s, well past the age of 30. While recalling my journey with this disease, I realized that the time lapse between then and now is 50 years – an entire generation.

When I think about all of the advancements that have been made, how far we have come in 50 years, I’m amazed. In one generation, Genentech discovered how to synthesize human insulin. The accuracy of glucose testing has improved drastically. Blood glucose monitors now allow us to monitor at home. While researchers have not found a cure yet, in their search for one, they have found ways to improve the lives of those of us living with this extremely difficult disease and I for one, am forever grateful.

Imagine if today, the 1.3 million people affected by this disease were still having to inject themselves with animal insulin? This is why funding research is so important and why I founded the Diabetes Research Connection. To offer hope and advancements and one day, a cure.

Find out more about the Diabetes Research Connection (DRC) and how to support our efforts by visiting https://diabetesresearchconnection.org/join-us/

Learn More +

OUR PROJECTS

See our approved research projects and campaigns.

Role of the integrated stress response in type 1 diabetes pathogenesis
In individuals with type 1 diabetes (T1D), the insulin-producing beta cells are spontaneously destroyed by their own immune system. The trigger that provokes the immune system to destroy the beta cells is unknown. However, accumulating evidence suggest that signals are perhaps first sent out by the stressed beta cells that eventually attracts the immune cells. Stressed cells adapt different stress mitigation systems as an adaptive response. However, when these adaptive responses go awry, it results in cell death. One of the stress response mechanisms, namely the integrated stress response (ISR) is activated under a variety of stressful stimuli to promote cell survival. However, when ISR is chronically activated, it can be damaging to the cells and can lead to cell death. The role of the ISR in the context of T1D is unknown. Therefore, in this DRC funded study, we propose to study the ISR in the beta cells to determine its role in propagating T1D.
Wearable Skin Fluorescence Imaging Patch for the Detection of Blood Glucose Level on an Engineered Skin Platform
zhang
A Potential Second Cure for T1D by Re-Educating the Patient’s Immune System
L Ferreira
Validating the Hypothesis to Cure T1D by Eliminating the Rejection of Cells From Another Person by Farming Beta Cells From a Patient’s Own Stem Cells
Han Zhu
Taming a Particularly Lethal Category of Cells May Reduce/Eliminate the Onset of T1D
JRDwyer 2022 Lab 1
Can the Inhibition of One Specific Body Gene Prevent Type 1 Diabetes?
Melanie
Is Cholesterol Exacerbating T1D by Reducing the Functionality and Regeneration Ability of Residual Beta Cells?
Regeneration Ability of Residual Beta Cells
A Call to Question… Is T1D Caused by Dysfunctionality of Two Pancreatic Cells (β and α)?
Xin Tong
Novel therapy initiative with potential path to preventing T1D by targeting TWO components of T1D development (autoimmune response and beta-cell survival)
flavia pecanha