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Artificial Pancreas

Are Artificial Pancreas Systems Effective in Treating Type 1 Diabetes?

There are many options available for treating type 1 diabetes from regular finger pricks and injections of insulin to continuous glucose monitoring systems to artificial pancreases and more. However, each person must find what works best for them in the management of their disease.

One treatment method that has undergone recent study is the use of artificial pancreas systems. According to researchers led by Eleni Bekiari, MD, Ph.D., at the Clinical Research and Evidence-Based Medicine Unit at the Aristotle University of Thessaloniki in Greece, these systems can provide positive results for some patients in managing their T1D. Throughout a series of 40 studies encompassing 1027 participants, artificial pancreas systems were found to not only be safe but also an effective line of treatment.

The study compared several different factors of single and dual hormone systems but mainly focused on the percentage of time normal glycemic levels were maintained. These results were measured against patients using standard insulin-based treatments. The study found that those individuals using the artificial pancreas systems experienced higher durations of time where their blood sugar levels were in the normoglycemic range, including overnight – 15.15% for artificial pancreas systems versus 9.62% for insulin-based treatment. There was also less deviation between blood sugar levels.

The researchers found that “artificial pancreas systems are an efficacious and safe approach for treating outpatients with type 1 diabetes.” More research and clinical trials are necessary to further explore the benefits and long-term outcomes of these systems. The Diabetes Research Connection is committed to supporting early career scientists in advancing their research and delving more deeply into topics related to the diagnosis, treatment, and management of type 1 diabetes. The DRC provides essential funding for researchers to carry out peer-reviewed, novel research projects. To learn more about current projects and support these efforts, visit http://diabetesresearchconnection.org.

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Role of the integrated stress response in type 1 diabetes pathogenesis
In individuals with type 1 diabetes (T1D), the insulin-producing beta cells are spontaneously destroyed by their own immune system. The trigger that provokes the immune system to destroy the beta cells is unknown. However, accumulating evidence suggest that signals are perhaps first sent out by the stressed beta cells that eventually attracts the immune cells. Stressed cells adapt different stress mitigation systems as an adaptive response. However, when these adaptive responses go awry, it results in cell death. One of the stress response mechanisms, namely the integrated stress response (ISR) is activated under a variety of stressful stimuli to promote cell survival. However, when ISR is chronically activated, it can be damaging to the cells and can lead to cell death. The role of the ISR in the context of T1D is unknown. Therefore, in this DRC funded study, we propose to study the ISR in the beta cells to determine its role in propagating T1D.
Wearable Skin Fluorescence Imaging Patch for the Detection of Blood Glucose Level on an Engineered Skin Platform
zhang
A Potential Second Cure for T1D by Re-Educating the Patient’s Immune System
L Ferreira
Validating the Hypothesis to Cure T1D by Eliminating the Rejection of Cells From Another Person by Farming Beta Cells From a Patient’s Own Stem Cells
Han Zhu
Taming a Particularly Lethal Category of Cells May Reduce/Eliminate the Onset of T1D
JRDwyer 2022 Lab 1
Can the Inhibition of One Specific Body Gene Prevent Type 1 Diabetes?
Melanie
Is Cholesterol Exacerbating T1D by Reducing the Functionality and Regeneration Ability of Residual Beta Cells?
Regeneration Ability of Residual Beta Cells
A Call to Question… Is T1D Caused by Dysfunctionality of Two Pancreatic Cells (β and α)?
Xin Tong
Novel therapy initiative with potential path to preventing T1D by targeting TWO components of T1D development (autoimmune response and beta-cell survival)
flavia pecanha