DRC & Research News

This page shares the latest news in T1D research and DRC’s community.

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Drone

Supporting Diabetes Management Via Drone

Type 1 diabetes (T1D) affects people from all walks of life around the world. A challenge in managing the disease is regular access to healthcare and necessary supplies. Healthcare providers in Ireland recognized the impact of this problem even more when natural disasters such as snowstorms, hurricanes, and flooding made it difficult for patients to reach clinics for their appointments or to get medications.

As a result, researchers turned to technology as a way to potentially help patients receive the care they need. They spent more than a year working out the logistics and regulatory compliance of using drones to deliver supplies to individuals in remote areas or those cut off from access following natural disasters or other incidents such as COVID-19. The researchers had to ensure that when using the drone, they were following all aviation and aerospace regulations, as well as medical and safety regulations.

The first flight traveled around 20 km each way going from Galway, Ireland, to the Aran Islands on September 13. The Wingcopter 178 drone delivered insulin from a pharmacy to a patient’s clinician and picked up a blood sample for remote testing of HbA1c levels. This test flight demonstrated that autonomous delivery of insulin is possible.

There was a significant amount of planning, research, and collaboration that went into making the drone delivery possible, but it is a starting point for making this technology available in healthcare. The researchers needed to have backup plans in place for each step of the process, and they worked closely with a multidisciplinary team including aviation and medication regulators.

However, this successful test flight is a stepping stone toward making drone delivery a reality for patients with diabetes. This could allow patients to continue receiving life-saving insulin and other supplies even when they are unable to make it out of their home. Diabetes does not take a break during pandemics or adverse events, and there are patients who live in rural communities where access to healthcare is a challenge.

Diabetes Research Connection (DRC) is excited to see how technology continues to improve and whether drone delivery becomes a feasible option as part of diabetes management and healthcare in general. The DRC provides funding for novel, peer-reviewed research studies focused on the prevention, cure, and improved management of type 1 diabetes. To learn more and support these efforts, visit https://diabetesresearchconnection.org.

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Role of the integrated stress response in type 1 diabetes pathogenesis
In individuals with type 1 diabetes (T1D), the insulin-producing beta cells are spontaneously destroyed by their own immune system. The trigger that provokes the immune system to destroy the beta cells is unknown. However, accumulating evidence suggest that signals are perhaps first sent out by the stressed beta cells that eventually attracts the immune cells. Stressed cells adapt different stress mitigation systems as an adaptive response. However, when these adaptive responses go awry, it results in cell death. One of the stress response mechanisms, namely the integrated stress response (ISR) is activated under a variety of stressful stimuli to promote cell survival. However, when ISR is chronically activated, it can be damaging to the cells and can lead to cell death. The role of the ISR in the context of T1D is unknown. Therefore, in this DRC funded study, we propose to study the ISR in the beta cells to determine its role in propagating T1D.
Wearable Skin Fluorescence Imaging Patch for the Detection of Blood Glucose Level on an Engineered Skin Platform
zhang
A Potential Second Cure for T1D by Re-Educating the Patient’s Immune System
L Ferreira
Validating the Hypothesis to Cure T1D by Eliminating the Rejection of Cells From Another Person by Farming Beta Cells From a Patient’s Own Stem Cells
Han Zhu
Taming a Particularly Lethal Category of Cells May Reduce/Eliminate the Onset of T1D
JRDwyer 2022 Lab 1
Can the Inhibition of One Specific Body Gene Prevent Type 1 Diabetes?
Melanie
Is Cholesterol Exacerbating T1D by Reducing the Functionality and Regeneration Ability of Residual Beta Cells?
Regeneration Ability of Residual Beta Cells
A Call to Question… Is T1D Caused by Dysfunctionality of Two Pancreatic Cells (β and α)?
Xin Tong
Novel therapy initiative with potential path to preventing T1D by targeting TWO components of T1D development (autoimmune response and beta-cell survival)
flavia pecanha