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Protecting Beta Cells

Protecting Pancreatic Beta Cells During Cell Transplantation

One of the hallmarks of type 1 diabetes (T1D) is the destruction of insulin-producing pancreatic beta cells. The immune system mistakenly attacks these cells leaving the body unable to regulate blood glucose levels naturally. Instead, insulin must be administered manually or via an insulin pump in order to prevent hyperglycemia.

Researchers have been experimenting with cell transplantation methods to replace these depleted cells and enable the body to produce its own insulin once again. A major obstacle to this approach is cell survival and viability. The stress of injecting the cells can cause cell death, and the body often treats the transplanted cells as foreign bodies and elicits an immune response to destroy them. Scientists have used various strategies for encapsulating the cells to reduce stress and protect them from the immune system. Some have been more effective than others.

new study examines the effectiveness of caging pancreatic islets in a multilayer hydrogel nanofilm. The nanofilm combines monophenol-modified glycol chitosan and hyaluronic acid to create a thin protective barrier that still enables oxygen and nutrients to flow into the caged cells while also allowing insulin and waste to flow out. In addition, it provides immunoisolation, eliminating the need for immunosuppressants.

When tested in T1D-induced mouse models, the nanofilm-caged spheroids were able to achieve normoglycemia compared to control groups. Scientists further evaluated their effectiveness by removing the kidney where the spheroids had been transplanted. As a result, the mice experienced hyperglycemia once again. Using a multilayer hydrogel nanofilm provided protection against mechanical stress and immune response while enabling the islets to regulate blood glucose levels.

Although this approach has only been tested on mouse models thus far, it provides a new approach for cell-based therapies. More research and testing are needed to determine if this transplantation method triggers the same effects in humans. It could one day open the door to new treatment options for individuals with type 1 diabetes.

Though not involved in this study, the Diabetes Research Connection (DRC) is committed to furthering research around T1D to improve diagnosis, treatment, and management of the disease and find a cure one day. The organization provides critical funding to early-career scientists pursuing novel research studies on T1D. Learn more and support current projects by visiting https://diabetesresearchconnection.org

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Dana Levin

Getting to know Fellow T1D – Dana Levin at Centura Wealth Advisory

Diabetes has taught me throughout my life to always have a backup plan for the backup plan. From the early days in 1994 when I was first diagnosed with T1D, my doctors always recommended keeping a snack and glucose tablets with me in case my blood sugars dipped low. To this day, my purse is always loaded with granola bars, nuts, and candy – it’s like a compact mini-mart. And it comes in handy often when restaurants take longer to bring the food than expected, and I’ve already bolused, or I find myself walking further on the beach than anticipated, and I feel my body starting to shake. When I travel, especially internationally, I make sure to keep a loaner insulin pump with me as well as pump and CGM supplies stashed in multiple suitcases and syringes with back up forms of insulin in case something crazy happens – and crazy, unexpected things always happen while traveling (it’s part of the adventure) and so long as I have my backups in place, my diabetes doesn’t have to control my life or plans.

As a newly diagnosed T1D at the age of 12, I never could have imagined how diabetes would impact the course of my career. Philanthropy has always been an essential part of my life, and giving back to the community was modeled for me at home by my parents, who were both educators in the public school system. My parents encouraged me to participate in many Walks for Diabetes and as part of the event, to send fundraising letters to friends and family. This annual exercise and leadership opportunity, coupled with many other volunteer experiences, guided me towards a career focused on philanthropy and giving back to the community. For 16 years, I worked as a fundraiser in a variety of nonprofit organizations, including one in the T1D space. I loved this work, and it has guided me to my current role at Centura Wealth Advisory as the Director of Philanthropic Strategies.

For the past year, I have been partnering with families to ensure that they have financial and philanthropic plans in place for their estate – both short and long-term. Together, we walk through conversations about their legacy and dreams as they plan for the future. The global pandemic of this past year has caused many families to either put living wills and trusts in place with a financial planner and estate attorney or to brush off older documents to ensure their intentions are still accurate. For those who have not done this yet, it is a highly recommended practice, so when life happens, financial decisions don’t need to be added to already stressful situations, medical or otherwise. This is having your backup plan in place, so to speak.

As someone with T1D, I never thought I would qualify for life insurance, one key component of an ultimate backup plan. I was concerned that if something happened to me, would my husband be able to pay our mortgage and take care of our family? Thankfully, a small handful of life insurance carriers will offer life insurance to people who live with T1D. Getting this coverage has provided me relief and comfort as well as filled a gap in my estate plan. With an A1c of 6.3, which I work on every single day, I focus on keeping myself as healthy and complication-free as possible; however, I know that as life changes, I can sleep better (despite my Dexcom beeping at me) because I have this coverage. In addition to partnering and supporting families at Centura as they build their estate plans, I am confident that my personal backup plan is also in place to provide for my family. I encourage everyone to have conversations with the trusted financial services professionals in your lives to ensure you have your plans in place so that you can live a more peaceful life.

Dana began working at Centura Wealth Advisory in 2020 as the Client Relationship Manager. She joined the team to bring together her passion for philanthropy with her commitment to help families build wealth and give back to the community. 

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Role of the integrated stress response in type 1 diabetes pathogenesis
In individuals with type 1 diabetes (T1D), the insulin-producing beta cells are spontaneously destroyed by their own immune system. The trigger that provokes the immune system to destroy the beta cells is unknown. However, accumulating evidence suggest that signals are perhaps first sent out by the stressed beta cells that eventually attracts the immune cells. Stressed cells adapt different stress mitigation systems as an adaptive response. However, when these adaptive responses go awry, it results in cell death. One of the stress response mechanisms, namely the integrated stress response (ISR) is activated under a variety of stressful stimuli to promote cell survival. However, when ISR is chronically activated, it can be damaging to the cells and can lead to cell death. The role of the ISR in the context of T1D is unknown. Therefore, in this DRC funded study, we propose to study the ISR in the beta cells to determine its role in propagating T1D.
Wearable Skin Fluorescence Imaging Patch for the Detection of Blood Glucose Level on an Engineered Skin Platform
zhang
A Potential Second Cure for T1D by Re-Educating the Patient’s Immune System
L Ferreira
Validating the Hypothesis to Cure T1D by Eliminating the Rejection of Cells From Another Person by Farming Beta Cells From a Patient’s Own Stem Cells
Han Zhu
Taming a Particularly Lethal Category of Cells May Reduce/Eliminate the Onset of T1D
JRDwyer 2022 Lab 1
Can the Inhibition of One Specific Body Gene Prevent Type 1 Diabetes?
Melanie
Is Cholesterol Exacerbating T1D by Reducing the Functionality and Regeneration Ability of Residual Beta Cells?
Regeneration Ability of Residual Beta Cells
A Call to Question… Is T1D Caused by Dysfunctionality of Two Pancreatic Cells (β and α)?
Xin Tong
Novel therapy initiative with potential path to preventing T1D by targeting TWO components of T1D development (autoimmune response and beta-cell survival)
flavia pecanha