DRC & Research News

This page shares the latest news in T1D research and DRC’s community.

Get the most recent diabetes research news, delivered straight to your inbox

Lab Research

A Multitude of Potential Treatment Options for Type 1 Diabetes

Type 1 diabetes is a condition that does not discriminate. It affects males and females of all races and ethnicities around the world. Researchers in many countries are striving to develop effective treatment options that help the body to regulate blood glucose on its own and reduce the need for constant monitoring and insulin injections. At the Kyoto Diabetes Mini-Symposium in June 2017, researchers presented various studies and their potential impacts. Here is an overview of some of the treatment options being explored:

Islet Transplantation: Islet transplantation is one option that scientists have been working on for many years. Patients receive infusions of human islet cells to replace the cells their bodies have mistakenly destroyed. Studies have shown that this approach has resulted in improved glycemic control and hypoglycemia awareness, as well as protection from severe hypoglycemic events in some patients. However, there are still challenges regarding the lifespan of the graphs and their prolonged effectiveness.

Cell Sourcing from Large Animals: One challenge that researchers have faced in islet transplantation is generating a sustainable amount of islet cells. Scientists have turned to large animals such as pigs to try to cultivate a new source. Studies have found that porcine islet cells function very similarly to human islet cells. However, there is concern over the potential transmission of porcine endogenous retroviruses, so scientists have been experimenting with gene editing to inactivate contributing sections of various genes and reduce risk.

Scientists are also exploring the possibility of generating a human pancreas inside a pig so that it will produce human islet cells. Similar studies have been done with rats and mice where each has developed a pancreas for the other. There are many ethical concerns and regulations to be considered with this approach, however.

Human Stem Cell-Derived Beta Cells: Scientists are exploring the potential of targeting human stem cells and guiding them into developing into pancreatic progenitor cells and eventually mature insulin-producing beta cells. Ideally, this would allow the body to better regulate its own blood glucose levels. Researchers are working on improving differentiation protocols and determining the best host conditions for the cells.

Cell Encapsulation: Current treatment involving transplantation requires patients to take medication that suppresses the immune system to keep it from attacking the transplanted cells or organs. While it protects the transplant, it puts patients at risk for a variety of complications. Scientists are working on a process to encapsulate islet cells in a device that protects them from an immune system attack. They are experimenting with different materials, locations, and processes to determine what may potentially work best.

These are just a few of the strategies scientists are investigating to help treat and potentially cure type 1 diabetes. There is still a lot more research and testing necessary to fully explore these options and their safety and efficacy. It is these types of innovative approaches that continue to advance knowledge and treatment regarding type 1 diabetes. The Diabetes Research Connection supports early career scientists in developing their research by providing essential funding. Click to learn more about current projects and provide support.

Learn More +
Thanksgiving Dinner Ethnic Family

A Diabetes-Friendly Thanksgiving

Food-heavy holidays, such as Thanksgiving, can be particularly hard for those with type 1 diabetes. Between carb-heavy foods, meals served at odd times to accommodate everyone’s schedules and perhaps even multiple meals with different sides of the family or groups of friends, keeping your blood sugar in check on Thanksgiving is no easy task.

However, with careful planning and some support from your family and friends, enjoying Thanksgiving doesn’t have to be difficult!

As you’re celebrating, keep the following in mind:

  • Don’t show up hungry.
  • Choose white meat turkey over dark meat, and skip the skin.
  • Opt for steamed vegetables over casseroles. For example, serve seasoned steamed green beans with salt, pepper and garlic powder instead of green bean casserole.

Thanksgiving Recipes

If you’re responsible for preparing a dish for a potluck or an entire Thanksgiving meal, consider these T1D-friendly takes on traditional Thanksgiving favorites.

Cauliflower Garlic Mashed Potatoes

Makes 4 servings.

  • 1 medium head cauliflower
  • 1 tablespoon cream cheese, softened
  • 1/4 cup grated Parmesan
  • 1/2 teaspoon minced garlic
  • 1/8 teaspoon straight chicken base or bullion (may substitute 1/2 teaspoon salt)
  • 1/8 teaspoon freshly ground black pepper
  • 1/2 teaspoon chopped fresh or dry chives, for garnish
  • 3 tablespoons unsalted butter
  1. Set a stockpot of water to boil over high heat.
  2. Clean and cut cauliflower into small pieces. Cook in boiling water for about 6 minutes, or until well done. Drain well; do not let cool and pat cooked cauliflower very dry between several layers of paper towels.
  3. In a bowl with an immersion blender, or in a food processor, puree the hot cauliflower with the cream cheese, Parmesan, garlic, chicken base, and pepper until almost smooth.
  4. Garnish with chives, and serve hot with pats of butter.

Nutrition (per serving): 149 calories, 11.5 g fat, 7 g saturated fat, 31 mg cholesterol, 170 mg sodium, 8 g carbohydrates, 4 g fiber, 4 g sugars, 5 g protein

Source: http://www.foodnetwork.com/recipes/mock-garlic-mashed-potatoes-recipe-1942447.

Pumpkin Pie (with Crust)

Makes 10 servings.

For the pie crust:

For the filling:

Make the Crust:

  1. Preheat your oven to 375 degrees F.  In the bowl of a food processor, pulse all crust ingredients EXCEPT egg to create thick crumbs, then pulse/process in the egg until a dough forms.
  2. Gather the dough into a ball, wrap in plastic, and chill in the refrigerator at least 20 minutes prior to rolling or pressing into your pie dish.
  3. To get the dough into your pie dish, you can either:
  4. Roll out the dough into a circle between two sheets of parchment. Place your pie dish upside-down over the dough, then using the bottom parchment paper, flip the dough into the dish. Finish by pressing it into the bottom and sides of the pie dish to fit – this dough will break easily since it lacks gluten, however, it also repairs incredibly easily and can withstand a lot of manipulation without affecting the final product! *
  5. If you don’t wish to roll out the dough (or find it tricky) you can simply press evenly into 9-inch pie dish using your hands.  Be patient and refrigerate dough as needed to make it easier to work with**
  6. Once pressed into the pie dish, gently pierce the dough with a fork all over so it doesn’t puff up while baking.
  7. Bake pie crust in 9” pie dish in the 375-degree oven for 12-15 mins until bottom is set, remove from oven and allow to cool for 5 minutes before pouring in filling.

Make the Filling:

  1. Whisk all ingredients except eggs, then whisk in eggs and egg yolk 1 at a time, don’t overmix.
  2. Pour filling into partially baked crust, spreading it all around to seal edges. Cover top with aluminum foil and bake (at 375 degrees F) 40-45 minutes or until center is nearly set (still a bit jiggly) and crust is deep golden brown.
  3. Allow to cool completely at room temperature to avoid excessive cracking of the filling. Once cooled, serve, or, cover and store in the refrigerator for up to 2 days prior to serving.

Recipe Notes

*Coconut sugar will cause the crust to darken more than maple sugar

**Unlike a traditional gluten-containing crust, you can’t “overwork” the dough, so take your time as needed pressing it into the pie dish

Nutrition (per serving) 302 calories, 21 g fat, 9 g saturated fat, 68 mg cholesterol, 5 g protein, 24 g carbohydrates, 10 g sugar, 3 g fiber, 144 mg sodium

Source: https://www.paleorunningmomma.com/classic-paleo-pumpkin-pie-crust-recipe/.

 

For more T1D-friendly recipes and eating tips, make sure to subscribe to our newsletter.

Learn More +

OUR PROJECTS

See our approved research projects and campaigns.

Role of the integrated stress response in type 1 diabetes pathogenesis
In individuals with type 1 diabetes (T1D), the insulin-producing beta cells are spontaneously destroyed by their own immune system. The trigger that provokes the immune system to destroy the beta cells is unknown. However, accumulating evidence suggest that signals are perhaps first sent out by the stressed beta cells that eventually attracts the immune cells. Stressed cells adapt different stress mitigation systems as an adaptive response. However, when these adaptive responses go awry, it results in cell death. One of the stress response mechanisms, namely the integrated stress response (ISR) is activated under a variety of stressful stimuli to promote cell survival. However, when ISR is chronically activated, it can be damaging to the cells and can lead to cell death. The role of the ISR in the context of T1D is unknown. Therefore, in this DRC funded study, we propose to study the ISR in the beta cells to determine its role in propagating T1D.
Wearable Skin Fluorescence Imaging Patch for the Detection of Blood Glucose Level on an Engineered Skin Platform
zhang
A Potential Second Cure for T1D by Re-Educating the Patient’s Immune System
L Ferreira
Validating the Hypothesis to Cure T1D by Eliminating the Rejection of Cells From Another Person by Farming Beta Cells From a Patient’s Own Stem Cells
Han Zhu
Taming a Particularly Lethal Category of Cells May Reduce/Eliminate the Onset of T1D
JRDwyer 2022 Lab 1
Can the Inhibition of One Specific Body Gene Prevent Type 1 Diabetes?
Melanie
Is Cholesterol Exacerbating T1D by Reducing the Functionality and Regeneration Ability of Residual Beta Cells?
Regeneration Ability of Residual Beta Cells
A Call to Question… Is T1D Caused by Dysfunctionality of Two Pancreatic Cells (β and α)?
Xin Tong
Novel therapy initiative with potential path to preventing T1D by targeting TWO components of T1D development (autoimmune response and beta-cell survival)
flavia pecanha