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Even Short-Term T2DM Remission Reduces Risk of Microvascular Dz

Original article published by Medical News Today on June 14, 2016. Click here to read the original article.

TUESDAY, June 14, 2016 (HealthDay News) — For patients with type 2 diabetes, remission after bariatric surgery is associated with a reduced risk of microvascular disease, even after subsequent relapse, according to a study published online June 6 in Diabetes Care.

Karen J. Coleman, Ph.D., from Kaiser Permanente Southern California in Pasadena, and colleagues conducted a retrospective observational cohort study involving 4,683 patients with type 2 diabetes who underwent bariatric surgery from 2001 through 2011. The correlation between type 2 diabetes remission/relapse status and the time to microvascular disease was assessed.

The researchers found that, compared with patients who never remitted, patients who experienced type 2 diabetes remission had a lower risk of incident microvascular disease (hazard ratio, 0.71). For patients who experienced a relapse after remission there was an inverse relationship between the length of time spent in remission and the risk of incident microvascular disease; the risk of microvascular disease was reduced for every additional year of time spent in remission prior to relapse (hazard ratio, 0.81), compared with patients who never remitted.

“Our results indicate that remission of type 2 diabetes after bariatric surgery confers benefits for risk of incident microvascular disease even if patients eventually experience a relapse of their type 2 diabetes,” the authors write.

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diabetes recipes

Finding the Best Recipes for a Diabetes Diet

Having type 1 diabetes or cooking for someone with type 1 diabetes doesn’t mean you’re stuck with bland, boring or tasteless food. Rather, eating moderate amounts of a variety of healthy, nutritious foods is key to keeping your insulin levels in check. In general, you’ll want to stick with nutrient-rich foods that are low in fat and calories, including fruits, vegetables and whole grains.

Finding Diabetic Friendly Recipes

We’ve compiled some of our favorite resources for finding the best diabetic recipes that fit into a diabetic diet.

Diabetic Foodie

Shelby, the writer behind Diabetic Foodie, was diagnosed with type 2 diabetes in 1999. She grew up eating southern food at nearly every meal, but after her diagnosis she quickly learned that eating healthy foods made managing her diabetes much easier. On her blog, Shelby provides recipes that generally follow the American Diabetes Association Guidelines, focusing primarily on lean protein, healthy fats and vegetables.

A Sweet Life

A Sweet Life is a diabetes magazine, and their website is packed full of great recipes for diabetics. Whether you’re looking for diabetic-friendly desserts, something low carb, or something to cook for a holiday, you’re sure to find it in their catalog of recipes. Plus, if you’re looking for a diabetic version of a specific recipe, just use their search feature to look for something diabetes-friendly!

Diabetes Self-Management

Diabetes Self-Management discusses multiple ways to manage your diabetes, but their recipes section is especially valuable. Recipes are diabetes-friendly and are divided into categories such as beverages, breakfast, desserts and sweets, main dishes, salads, sides, snacks and appetizers and soups and stews.

T1 Everyday Magic

T1 Everyday Magic is a special resource from Lilly Diabetes and Disney, and is specifically geared toward parents of children with type 1 diabetes. While the site includes resources for parents of newly-diagnosed children, information about general daily living and a large section devoted to recipes for children with diabetes. These recipes are kid-friendly, and include foods such as waffled eggs, chocolate avocado truffle spoons, peanut butter rice cereal bars and holiday-specific classroom treats.

For more great resources on diabetes-friendly recipes and other aspects of living with type 1 diabetes, sign up for the Diabetes Research Connection newsletter.

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See our approved research projects and campaigns.

Role of the integrated stress response in type 1 diabetes pathogenesis
In individuals with type 1 diabetes (T1D), the insulin-producing beta cells are spontaneously destroyed by their own immune system. The trigger that provokes the immune system to destroy the beta cells is unknown. However, accumulating evidence suggest that signals are perhaps first sent out by the stressed beta cells that eventually attracts the immune cells. Stressed cells adapt different stress mitigation systems as an adaptive response. However, when these adaptive responses go awry, it results in cell death. One of the stress response mechanisms, namely the integrated stress response (ISR) is activated under a variety of stressful stimuli to promote cell survival. However, when ISR is chronically activated, it can be damaging to the cells and can lead to cell death. The role of the ISR in the context of T1D is unknown. Therefore, in this DRC funded study, we propose to study the ISR in the beta cells to determine its role in propagating T1D.
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