DRC & Research News

Patients with diabetes rely on blood sugar information to make decisions on insulin therapy. Standard of care to read blood sugar includes finger pricking for a glucose meter or a wearable continuous glucose monitoring (CGM) device. While CGM devices have been a major technological improvement for glucose monitoring, the current FDA-approved sensors have limitations. The two current types of CGM sensors are electrochemical and optical sensors. The Dexcom G6, FreeStyle Libre 3, and Medtronic Guardian 3 are all electrochemical sensors. This type of device can have insufficient stability in the body, is susceptible to corrosion, has poor accuracy at low glucose, and can have interference which requires frequent calibration with a glucose meter.

To address these technological limitations, we designed a new type of optical CGM that includes a fluorescent nanodiamond boronic hydrogel system in porous microneedles. Fluorescent nanodiamonds are an inexpensive material that is easy for larger-scale synthesis. The fluorescent nanodiamonds make a stable signal that can be detected and are compatible for use inside the body. The boronic hydrogel is a polymer material that can detect changes in glucose levels. This study attached a boronic hydrogel to a nanodiamond to make a novel fluorescent CGM device. In our proof-of-concept studies, we showed that we can reliably measure blood sugar levels in a mouse for up to 30 days. Also, in large animal models, we showed that the device left minimal scar tissue. Lastly, the hydrogels that we used can be chemically adjusted to detect other biological signals, making it an attractive platform for noninvasive biomedical monitoring. This type of system can be used as a diagnostic tool for other diseases, such as cancer.

In summary, our proof-of-concept study shows that a microneedle device with this material can serve as a minimally invasive and long-lasting fluorescence sensor for measuring blood sugar. Our sensor is small and easy to apply/remove, providing a safer and more user-friendly optical CGM device for diabetes patients. This work was recently published in Advanced Science in an article called “Continuous Glucose Monitoring Enabled by Fluorescent Nanodiamond Boronic Hydrogel.”

Type 2 diabetes, a condition characterized by the body’s inability to properly use insulin, affects millions of people worldwide. Despite its prevalence, it’s often misunderstood, leading to a variety of misconceptions that can perpetuate stigma and impede effective management of the disease.

Our aim at the Diabetes Research Connection is to not only fund groundbreaking research into Type 1 and Type 2 diabetes but also to provide accurate, reliable information that educates the public and combats these pervasive myths. This blog post is part of that mission.

In this post, we’ll debunk some of the most common myths surrounding Type 2 diabetes, offering trusted insights backed by science. Our goal is to replace misinformation with facts, fostering a better understanding of the condition and promoting healthier, more informed conversations about it.

For in-depth information about Type 2 diabetes, its causes, symptoms, treatment, and management, visit the Diabetes Research Connection website. Equipped with the right knowledge, we can collectively make strides in battling this widespread disease.

Myth 1: Only Overweight People Get Type 2 Diabetes

One of the most common misconceptions about Type 2 diabetes is that it’s a disease that only affects overweight or obese individuals. While it’s true that excess weight can be a risk factor for developing Type 2 diabetes, it’s certainly not the only one. There are several other factors, including age, family history, ethnicity, and even certain health conditions, that can also increase the risk of developing this type of diabetes.

Research funded by the Diabetes Research Connection has shown that people of all shapes, sizes, and fitness levels can, and do, develop Type 2 diabetes. Focusing solely on weight can result in an oversimplified view of the disease and delay diagnosis and treatment for those who don’t fit the stereotype.

Understanding the full range of risk factors for Type 2 diabetes is essential for early detection and treatment. Consider making a donation to the Diabetes Research Connection to support ongoing research into these risk factors, as well as efforts to educate the public about the realities of this disease.

Myth 2: Type 2 Diabetes is not as Serious as Type 1

Another misconception is the belief that Type 2 diabetes is somehow less serious than Type 1. This myth is not only misleading but also potentially harmful. Both types of diabetes can lead to serious, even life-threatening complications if not managed correctly.

While the onset and management strategies for Type 1 and Type 2 diabetes may differ, both types require diligent care and attention. The Diabetes Research Connection is committed to conducting and supporting research into both Type 1 and Type 2 diabetes, seeking innovative treatments and, ultimately, a cure.

Help us dispel myths about Type 2 diabetes by sharing this post. By spreading accurate information, we can ensure that everyone living with diabetes gets the understanding and support they need.

Myth 3: People with Type 2 Diabetes Can’t Eat Sugar at All

The notion that people with Type 2 diabetes must completely eliminate sugar from their diet is another widely held myth. In reality, while it’s important for people with Type 2 diabetes to monitor their carbohydrate intake, including sugars, a zero-sugar diet is not necessary.

The key lies in moderation and balance. A healthy diet for people with Type 2 diabetes can still include some sugar, as long as it’s part of a balanced, nutrient-dense diet, and blood sugar levels are carefully managed.

Insights from Diabetes Research Connection-backed studies emphasize the importance of a personalized approach to dietary management in Type 2 diabetes, one that takes into account individual needs, preferences, and lifestyle.

To learn more about nutrition and diet management for Type 2 diabetes, visit the Diabetes Research Connection website. You’ll find a wealth of information backed by science, providing you with reliable guidelines for a diabetes-friendly diet.

Myth 4: If You Have Type 2 Diabetes, You Must Only Use Insulin

While insulin therapy can be a part of Type 2 diabetes management, it’s certainly not the only treatment option. Many people with Type 2 diabetes can manage their blood sugar levels through lifestyle changes, oral medications, or non-insulin injectable drugs.

Insulin is typically introduced when other measures are no longer sufficient to keep blood sugar levels in check. The Diabetes Research Connection funds research into a wide variety of treatment options for Type 2 diabetes, from exploring new drug therapies to studying the impact of lifestyle modifications.

To support further research into diverse and more effective treatment options for Type 2 diabetes, consider making a donation to the Diabetes Research Connection. Your contribution could play a part in the next major breakthrough in diabetes care.

Myth 5: Type 2 Diabetes is Only a Problem for Adults

While Type 2 diabetes was once predominantly seen in adults, it’s a growing problem among children and adolescents. Sedentary lifestyles and a rise in obesity rates have contributed to an increase in Type 2 diabetes cases in younger age groups.

Studies funded by the Diabetes Research Connection are actively exploring this worrying trend, aiming to understand the unique challenges and implications of Type 2 diabetes in youth. This knowledge is crucial for developing targeted prevention strategies and effective treatments for this younger population.

Keep yourself updated on the latest research and developments in Type 2 diabetes by signing up for the Diabetes Research Connection newsletter. The more we know, the better we can work together to combat this disease across all age groups.

Looking forward

Dispelling myths about Type 2 diabetes is crucial for fostering a better understanding of the disease and promoting effective management strategies. The Diabetes Research Connection is committed to providing accurate and reliable information, supported by scientific research, to help educate the public and debunk misconceptions.

By challenging myths such as the belief that only overweight individuals get Type 2 diabetes or that it is less serious than Type 1 diabetes, we can break down barriers and promote a more inclusive and empathetic approach to diabetes care. Understanding that sugar can still be enjoyed in moderation and that treatment options go beyond insulin empowers individuals with Type 2 diabetes to make informed decisions about their health.

As supporters of the Diabetes Research Connection, your contributions play a vital role in advancing our understanding of Type 2 diabetes and developing innovative treatments. Together, we can work towards a future where accurate information and effective interventions make a tangible difference in the lives of those affected by Type 2 diabetes.

Visit the Diabetes Research Connection website to learn more about Type 2 diabetes, its management, and the ongoing research supported by donations. Consider making a donation to support their mission of improving lives through research and education. By doing so, you contribute to the fight against Type 2 diabetes and help create a world where misconceptions are replaced with knowledge and understanding.

A New Path with Diabetes

Every year, millions of people receive a life-changing diagnosis: diabetes. This news can be daunting, not just for the person diagnosed, but also for their loved ones. As family and friends, it’s natural to want to offer support and help. However, understanding how best to do that can sometimes be challenging, especially when you’re new to the world of diabetes.

This guide, “How to Support a Loved One Diagnosed with Diabetes” aims to provide practical strategies to help you navigate this new journey. Whether your loved one is dealing with Type 1 or Type 2, this guide offers insights on providing emotional support, aiding in diabetes management, and promoting a healthier lifestyle.

Importantly, it’s crucial to remember that you’re not alone. There is a wealth of information, resources, and a supportive community available on the Diabetes Research Connection website to help you and your loved one during this time. Together, we can ensure that a diagnosis of diabetes becomes a starting point for positive lifestyle changes and not an end to living a fulfilling life. Let’s get started.

Understanding Type 1 and Type 2 Diabetes

Before diving into how to support your loved one, let’s start by understanding the basics of Type 1 and Type 2.

Type 1: This is an autoimmune condition where the body’s immune system attacks and destroys the insulin-producing cells in the pancreas. People with Type 1 diabetes need to take insulin every day to stay alive.

Type 2: This is a chronic condition that affects the way the body processes blood sugar (glucose). The body either resists the effects of insulin or doesn’t produce enough insulin to maintain normal glucose levels.

Understanding these differences is essential because it will shape the way you support your loved one. The needs of someone with Type 1 diabetes can vary greatly from those with Type 2.

Further information about both types of diabetes is available on the Diabetes Research Connection website. You’ll find a wealth of resources that break down the complexities of these conditions, making them easy to understand. Take some time to get acquainted with this knowledge – it’s your first step in supporting your loved one effectively.

Remember, diabetes research is continuously evolving, bringing new insights and treatments. By making a donation to the Diabetes Research Connection, you can support this vital work, contributing to better outcomes for people living with this disease.

Learning about Diabetes Management

Knowledge is power, especially when it comes to managing diabetes. The more you understand diabetes management, the better positioned you will be to offer meaningful and practical support. Here are some areas to focus on:

Diet and Nutrition: Learn about the impact of different foods on blood sugar levels, and understand how to balance meals for someone with diabetes.

Exercise: Regular physical activity is a cornerstone of diabetes management. Understand the best exercises for people with diabetes and how to incorporate them safely into their routine.

Medication Management: Whether it’s insulin injections for Type 1 diabetes or oral medication for Type 2, understanding medication schedules and potential side effects is crucial.

Blood Sugar Monitoring: Learn about how and when to check blood glucose levels and what the readings mean.

Remember, everyone’s experience with diabetes is different, and what works for one person may not work for another. Be patient, keep learning, and stay flexible.

The Diabetes Research Connection offers various educational resources, from detailed articles to community forums where you can ask questions and share experiences. Don’t forget to make use of these tools, and consider making a donation to help us continue providing these resources for those supporting a loved one with diabetes. Let’s learn together, for the ones we love.

Being There for Your Loved One

Living with diabetes can take an emotional toll. Your loved one might experience a range of emotions from fear and anger to sadness and even denial. As a support system, one of your most important roles is to provide emotional support. Here’s how you can do that:

Listen: Sometimes, the best support you can offer is a listening ear. Encourage your loved one to express their feelings and concerns about living with diabetes.

Empathize: Try to understand their perspective. Empathy can help create an environment where your loved one feels safe and supported.

Reassure: Assure them that it’s normal to have these feelings and that they’re not alone. Remind them of their strengths and capabilities.

Encourage Positivity: Help them see the positive aspects of managing their diabetes, such as adopting healthier habits that can enhance their overall quality of life.

Supporting your loved one emotionally can make a significant difference in their journey with diabetes. But remember, it’s also essential to take care of your emotional health.

The Diabetes Research Connection can provide resources and a supportive community to help both you and your loved one cope with the emotional aspects of diabetes. Consider joining this community and, if possible, make a donation to help maintain these valuable resources. Together, we can ensure that everyone affected by diabetes receives the emotional support they need.

Supporting Dietary and Exercise Changes

A cornerstone of managing both Type 1 and Type 2 diabetes is adopting a healthy lifestyle. This often involves making changes in diet and physical activity. Here’s how you can support your loved one in this aspect:

Dietary Changes: Understand the importance of balanced nutrition in managing blood glucose levels. Assist in meal planning and preparation, focusing on foods that are high in nutrients and low in sugar and unhealthy fats.

Exercise Regularly: Encourage regular physical activity. Whether it’s a walk in the park, a yoga session, or a dance class, find something enjoyable that keeps them moving.

Consistency is Key: Consistency in meal times and exercise routines can greatly help in maintaining stable blood sugar levels. Help them establish and stick to regular eating and exercise schedules.

Learn Together: Explore new healthy recipes and fun ways to be active together. This shared journey can be a great bonding experience and make the process more enjoyable.

By supporting your loved one in making these changes, you not only help them manage their diabetes but also promote a healthier lifestyle for everyone involved.

Don’t forget to visit the Diabetes Research Connection for more tips and resources on promoting a healthy lifestyle for individuals with diabetes. And consider making a donation to help us continue providing these important resources to the community. Your support could transform a life.

Helping with Medication and Doctor Visits

Managing diabetes often involves regular medications and frequent doctor visits. Supporting your loved one in this aspect is key to ensuring they remain healthy. Here’s how you can help:

Medication Reminders: Help your loved one remember to take their medication at the right times, especially if they’re on a strict schedule.

Understanding Medications: Learn about the medications your loved one is taking. This includes knowing what each medication does, potential side effects, and how they interact with food and other medicines.

Doctor Visits: Accompany your loved one to their doctor appointments when possible. You can provide emotional support, help remember the doctor’s advice, and ask any questions that your loved one might forget.

Staying Updated: Stay updated with the latest research and advancements in diabetes treatment. This can help when discussing treatment options with healthcare providers.

Supporting your loved one’s medical needs can significantly impact their health and quality of life. Your support not only helps them feel cared for but also ensures they’re getting the best possible care.

Remember, the Diabetes Research Connection is here to provide you with the latest information and resources to help you support your loved one in their medical journey. We also encourage you to consider making a donation. Your contribution can help fund critical research to improve diabetes care and treatment. Let’s make a difference together.

Your Role in Their Diabetes Journey

Supporting a loved one with diabetes is a journey filled with challenges, learning, and growth. Your role as a pillar of strength in their diabetes journey is invaluable, and your active involvement can make a huge difference in their life.

Remember, diabetes doesn’t define your loved one. They can still live a fulfilling and active life with your support, a positive mindset, and the right management strategies. Your patience, understanding, and encouragement can provide the strength they need to successfully manage their diabetes.

Finally, as we have explored in this guide, the Diabetes Research Connection offers a wealth of resources for both people living with diabetes and their loved ones. Becoming part of this supportive community can be an excellent way to continue learning and sharing experiences.

Make a donation to help further diabetes research and continue the invaluable work of the Diabetes Research Connection. Every donation makes a difference and brings us one step closer to a world where diabetes doesn’t limit anyone. Your support, in every form, is a beacon of hope. Let’s stand strong together, for ourselves and our loved ones.

The Importance of Continuous Learning and Engagement

Living with diabetes or supporting a loved one with the disease is an ongoing journey. The landscape of diabetes care and management is continuously evolving, with new research and advancements providing better ways to manage the condition.

Staying updated with this evolving knowledge is a crucial part of this journey. It can help you support your loved one more effectively and make informed decisions about their care.

Stay Informed: Regularly check reputable sources, like the Diabetes Research Connection, for updates on diabetes research and management strategies.

Community Involvement: Engage with the diabetes community. Sharing experiences and tips with others in similar situations can provide valuable insights and emotional support.

Ongoing Education: Attend workshops, webinars, or courses on diabetes management to keep your knowledge current.

Remember, your active engagement and continuous learning can make a significant difference in your loved one’s diabetes journey.

Visit the Diabetes Research Connection website today for a wealth of resources and the latest updates on diabetes research. If you can, consider making a donation. Your support could provide hope to millions of people living with diabetes and bring us closer to a future where diabetes is no longer a limitation. Let’s continue this journey together, stronger and more informed.

Transforming Challenges into Opportunities

Supporting a loved one with diabetes may seem challenging, but it’s important to remember that every challenge presents an opportunity for growth, connection, and positive change. By offering your support, you’re not only helping your loved one manage their diabetes but also strengthening your bond with them.

You’re helping them live a healthier lifestyle, encouraging them to stay positive, and showing them they’re not alone in their journey. All these aspects can significantly improve their quality of life and overall well-being.

Remember, the Diabetes Research Connection is always here to help, with a wealth of resources and a supportive community. We invite you to join us, learn from us, and share your experiences with us.

And lastly, consider making a donation to support diabetes research. It is through your generous contributions that we can continue our work, bring hope to those living with diabetes, and strive for a future where diabetes doesn’t limit anyone.

Thank you for being a part of this journey, for your support, and for making a difference. Together, we are strong. Together, we can transform challenges into opportunities. Visit the Diabetes Research Connection today to learn more, share, and contribute. Let’s build a better future together.

Big Picture

· On June 28, the FDA approved Lantidra, which is the first cellular therapy to treat type one diabetes. (FDA Press release)

· 21 out of 30 participants who received Lantidra treatment did not need to take insulin for at least a year, including 10 participants who did not need to take insulin for more than five years.

How does this cellular therapy work?

Pancreatic cells from a deceased donor are transplanted into a patient with T1D to replace insulin-producing beta cells, which help control blood glucose (BG) levels. Lantidra is the first commercialized therapy. It builds on decades of experimental islet cell transplants.

Who is eligible to receive Lantidra?

Patients with T1D need daily insulin therapy. Some develop hypoglycemic unawareness, which may lead to sudden and severe low BG levels, which may result in a coma, seizures, or death. The FDA approved Latidra treatment only for adults with T1D and hypoglycemic unawareness.

How well does Lantidra work?

Lantidra therapy was tested in two non-randomized studies. Each T1D participant with hypoglycemic unawareness received 1-3 infusions of Lantidra. The goal was for participants to become insulin independent, eliminating the need for daily insulin injections and self-regulation of BG without patient intervention. Five participants never became insulin-independent, 21 were insulin independent for a year or more, 11 were insulin independent for 1-5 years, and 10 were insulin independent for over 5 years.

Does Lantidra have side effects?

One major drawback of this therapy is the need for immunosuppression drugs to prevent rejection of the transplanted islets. The intensity of these side effects related to the number of infusions received. The number and severity of side effects varied and included nausea, diarrhea, fatigue, anemia, and abdominal pain. Some severe complications required stopping the use of immunosuppressants, which caused the death of the transplanted cells and loss of insulin independence. A majority of participants reported at least one serious negative effect from the combined Lantidra and immunosuppressant therapy.

How will this FDA approval impact type 1 diabetes therapy?

Since Latidra is approved only for T1Ds with hypoglycemic unawareness and is likely to be expensive, this therapy will help a small percentage of those with T1D to achieve insulin independence. Continuous glucose monitoring and automated insulin devices may also alleviate the hypoglycemic unawareness issue but is not a cure.

Where do we go from here?

Considerably more research is needed to develop a safe, cost-effective T1D cure without immunosuppression. Vetted, novel approaches are supported by DRC donors. Cures may include artificial beta cells, immune-privileged islet cells generated from stem cells, smart insulin and other potential therapies to universally treat individuals living with T1D. DRC continues to monitor advancements and fund innovative approaches to end T1D.

Vincenzo Cirulli and Alberto Hayek, the current and past Chairs of DRC’s Scientific Review Committee, comment on FDA approval of Lantidra:

Lantidra’s cadaveric islet transplant technology was first published in 2000 during the Edmonton trials. It has not progressed much since then, other than some improvement in drugs used to address the rejection of transplanted islet tissue. The rapidly evolving progress witnessed over the past few years with stem cell-derived islet cells, currently being used in pilot clinical studies, indicate that stem cell-derived islets will likely supplant cadaveric islets transplants very soon. Unlike cadaveric islets, an exciting advantage of stem cell-derived islet cells is that they are amenable to genetic and epigenetic modification to allow their engraftment without the need for immunosuppression, and possibly prevent the recurrence of autoimmunity. This, although at an early stage, is an avenue of translational research that is likely to lead to a permanent cure for T1D. In the meantime, T1D researchers must be adequately supplied with high quality cadaveric islets for their research, as they will continue to provide a gold-standard quality control to monitor and compare the functional maturity of stem cell-derived islet tissue.

How will competition for this very limited resource be allocated, and at what cost? DRC will continue to support peer-reviewed, innovative, and unbiased solid science to finally put an end to T1D.

Diabetes Research Connection’s next round of type 1 diabetes (T1D) research funding has begun.  We are excited to announce that our 2023 Request for Application (RFA) period is NOW OPEN! 

We sent out notifications to hundreds of research institutes and T1D scientists around the country, encouraging all early-career investigators to submit their proposals for research grant funding.

Our investment in research is focused on innovation, and we are funding more research than ever – encouraging fresh ideas and providing the means for a new generation of diabetes investigators to go where no one else is going to solve the complex diabetes puzzle. If they have an innovative idea – we will help get it funded!

Last year alone, DRC committed to funding eleven new projects from all across the country.

We will not stop until diabetes is eliminated, and your generous contributions allow us to continue progressing forward in that goal.

If you would like to support our next group of brilliant minds committed to T1D cures, please make a gift today. Click DONATE NOW on the top right of this page.

If you are a researcher and would like to submit your proposal, click HERE.

Join us in cheering on these new T1D researchers! 

Every year, hundreds of new T1D researchers for our prestigious research grant. This year, we were thrilled to review an impressive array of applications, each one promising a potential breakthrough. Today, it is with great joy that we announce our newest research grant awardees!

Announcing the Awardees

Context of the Research Grant

The research grant is an annual offering by our organization to support innovative minds in their journey to make significant contributions to their field. Ever wondered how life-changing discoveries come to be? It’s through such opportunities, where researchers are given the funding and support they need to explore and experiment.

Overview of the Selection Process

The selection process was a rigorous one, encompassing several rounds of reviews and interviews. It’s no walk in the park; our panel of experienced judges critically evaluated each proposal based on originality, feasibility, potential impact, and the applicant’s capability to carry out the research.

The Importance of Research Grants

Research grants are vital to advancing knowledge in various fields. They provide resources for innovators to push the boundaries of what we know and understand. It’s like giving wings to those poised on the edge of discovery. Who knows where these wings might carry them?

Future Opportunities for Aspiring Applicants

Are you intrigued by the accomplishments of our awardees and inspired to create your own wave in your field of interest? We encourage you to apply in the future. Remember, the world of innovation and discovery is always ripe with opportunities, like a tree laden with fruit waiting to be picked.

Conclusion

We congratulate our newest t1d researchers who won grants once again. Their passion, creativity, and dedication to their respective fields are indeed inspiring. As we look forward to the fruits of their research, we remain committed to fostering innovation and nurturing talent through our annual research grants. After all, who knows? The next game-changing discovery could be just an application away!

FAQs

1. How can I apply for the research grant?
   • Details about the application process will be published on our website during the application period.
2. What are the eligibility criteria for the research grant?
   • The criteria may vary annually, but typically, we look for innovative, impactful proposals and capable applicants.
3. How are the research grant awardees selected?
   • The awardees are chosen through a rigorous selection process involving multiple rounds of reviews and interviews.
4. Can international applicants apply for the research grant?
   • Yes, our research grant is open to international applicants.
5. When is the next application period?
   • The dates for the next application period will be announced on our website.

We look forward to following their progress.

Look for future emails that will highlight their projects in more detail.

For questions or information on other ways to give such gifts via stock or donor-advised funds, contact Christine Rhoads at crhoads@diabetesresearchconnection.org.

All gifts to DRC are 100% tax-deductible.  DRC is a 501(c)(3) charitable organization / Tax ID#90-0815395.

Approximately half of the people with type 1 or type 2 diabetes experience peripheral neuropathy—weakness, numbness, and pain, primarily in the hands and feet.  New discoveries by a team of researchers at Salk Research Institute may provide a new way to identify people at high risk for peripheral neuropathy and a potential treatment option.

Read here for more information on this study, authored by a distinguished team of researchers, including senior researcher and Diabetes Research Connection founder and board member                     Nigel Calcutt.