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pasta e fagioli

Winter Comfort Food Recipes for Those with Type 1 Diabetes

Now that the holidays are over and we’re deep into winter, you’re probably finding yourself craving warm, rich, delicious comfort food. Hearty soups, chili with cornbread, macaroni and cheese, chicken pot pie, pasta, baked potatoes – we all have our favorite foods and meals for when it’s chilly outside.

However, for those of us with type 1 diabetes, indulging in our favorite comfort food can be a bit more complicated, especially when so much of these foods are carb-heavy.

Below we’ve compiled some of our favorite T1D-friendly comfort foods for the colder winter months.

Pasta e Fagioli

Taken from Diabetic Living.

Pasta e Fagioli is a traditional pasta and bean soup that is perfect for warming up on a cold night.

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Makes: 8 servings

Ingredients

1 tablespoon olive oil
2 ounces prosciutto or turkey bacon, chopped
2 cups chopped onions (2 large)
1/2 cup chopped celery (1 stalk)
1/2 cup chopped carrot (1 medium)
2 tablespoons bottled minced garlic
1 tablespoon dried oregano, crushed
1 teaspoon anchovy paste (optional)
1 teaspoon crushed red pepper
2 14 – ounce can reduced-sodium chicken broth
1 28 – ounce can no-salt-added diced tomatoes, undrained
1 cup whole grain medium pasta shells
2 15 – ounce can no-salt-added cannellini beans (white kidney beans), rinsed and drained
1/2 cup snipped fresh parsley
2 tablespoons lemon juice
1/4 cup finely shredded Parmesan cheese (1 ounce)

  1. In a Dutch oven, heat oil over medium-high heat. Add prosciutto; cook for 2 to 3 minutes or until crisp. Using a slotted spoon, transfer prosciutto to paper towels; let drain. Set aside.
  2. Add onions, celery, carrot, and garlic to the Dutch oven; cook over medium heat for 3 to 4 minutes or until softened, stirring frequently. Stir in oregano, anchovy paste (if desired), and crushed red pepper. Cook and stir for 1 minute. Add broth, tomatoes and pasta shells. Bring to boiling; reduce heat. Simmer, uncovered, about 15 minutes or until pasta is tender.
  3. Meanwhile, use a fork to mash one can of the beans. Stir the whole and mashed beans into pasta mixture. Simmer about 5 minutes or until heated through.
  4. Stir in parsley and lemon juice. Immediately ladle into serving bowls. Sprinkle with Parmesan and the prosciutto.

Nutrition (per serving): 235 calories, 5 g fat, 3 g saturated fat, 2 mg cholesterol, 490 mg sodium, 35 g carbohydrates, 9 g fiber, 7 g sugars, 13 g protein

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Classic Beef Stroganoff

Taken from Diabetic Living.

Beef Stroganoff is a hearty, creamy beef dish, and this slow-cooker recipe makes it perfect for enjoying on a busy weeknight!

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Makes: 6 servings

Ingredients

1 1/4 pounds beef stew meat
2 teaspoons vegetable oil
2 1/2 cups sliced fresh mushrooms
1/2 cup sliced green onions (4) or chopped onion (1 medium)
1 bay leaf
2 cloves garlic, minced
1/2 teaspoon dried oregano, crushed
1/4 teaspoon salt
1/4 teaspoon dried thyme, crushed
1/4 teaspoon black pepper
1 1/2 cups 50% less sodium beef broth
1/4 cup dry sherry
1 8 – ounce carton light sour cream
1/3 cup all-purpose flour
1/4 cup water
Sauteed zucchini “noodles” or hot cooked whole wheat pasta
Snipped fresh parsley or basil (optional)

  1. Cut up any large pieces of meat. In a large nonstick skillet, cook half of the meat in hot oil over medium-high heat until brown. Using a slotted spoon, remove meat from skillet. Repeat with the remaining meat. Drain off fat. Set meat aside.
  2. In a 3-1/2- or 4-quart slow cooker combine mushrooms, green onions, bay leaf, garlic, oregano, salt, thyme, and pepper. Add meat. Pour broth and sherry over mixture in cooker.
  3. Cover and cook on low-heat setting for 8 to 10 hours or on high-heat setting for 4 to 5 hours. Remove and discard bay leaf.
  4. If using low-heat setting, turn to high-heat setting. In a medium bowl stir together sour cream, flour, and the water until smooth. Gradually stir about 1 cup of the hot broth into sour cream mixture. Return sour cream mixture to cooker; stir to combine. Cover and cook about 30 minutes more or until thickened and bubbly. Serve over sauteed zucchini and, if desired, sprinkle with parsley.

Nutrition (per serving): 257 calories, 10 g total fat, 5 g saturated fat, 74 mg cholesterol, 312 mg sodium, 14 g carbohydrates, 2 g fiber, 4 g sugars, 26 g protein

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square drc year in review

Diabetes Research Connection 2016 Year in Review

This past year has been a big one for us at Diabetes Research Connection. Our donors have stepped up to the plate and helped us fund research towards treating, curing and preventing type 1 diabetes. In fact, in 2016 we were able to raise more than $490,000 thanks to the support of our donors.

We’re committed to keeping our backers updated on all projects and DRC happenings, so we wanted to take time at the beginning of 2017 to remind ourselves and our donors of all the amazing things that happened in 2016.

In January, Sangeeta Dhawan, Ph.D. at UCLA School of Medicine started off the year with her project, Making More and Better Insulin Producing Cells with Cell Regeneration. We were able to help her raise more than $30,000.

Dr. Sangeeta Dhawan

 

In February, we launched another project, Replacement Beta-Cells From An Unexpected Source, a research study conducted by Joseph Lancman, Ph.D. — Sanford Burnham Prebys Medical Discovery Institute. We were able to raise more than $45,000 in support of this project.

Dr.Lancman in Lab

In April, we celebrated World Health Day. This year’s theme was Beat Diabetes, and we encouraged our donors and supporters to get involved in the global fight against diabetes.

In May, another project launched, and we were able to help Peter Thompson, Ph.D. at University of California San Francisco raise more than $30,000 for his project, Regrowth of Beta Cells with Small Molecule Therapy.

Peter Thompson - Regrowth of beta cells with small molecule therapy

Another new project came online in July; Agata Jurcyzk, Ph.D. of the University of Massachusetts Medical School, What is the Connection Between T1D and Depression?

Agata-Headshot

August was a busy month for us at DRC. In mid-August, we partnered with the diaTribe Foundation for Brews & Blood Sugar. More than 100 people joined us to samples beer from one of San Diego’s premier breweries, to learn how different varieties of beer affect blood sugar and support efforts to find solutions for those with diabetes. We also launched our T1D resource center in August, where we’ve curated the best information out there pertaining to T1D. Lastly, we launched a project to raise funds for Gene-Specific Models and Therapies for Type 1 Diabetes, research being conducted by Jeremy Racine, Ph.D. of The Jackson Laboratory.

jeremy_racine_lab

In September, we were honored to be featured by The Huffington Post. We also launched our campaign on Gladitood, which helped us raise money and support for our General Fund as we began to close out the year.

In November, we celebrated National Diabetes Month. As a part of these celebrations, we launched our Double Your Dollars campaign, where every dollar donated to the General Fund was matched 100%. We upped the ante on Cyber Monday, doubling each match, making donations go even further. All told, we raised more than $80,000 in November. Additionally, we hosted a Crowdfunding Science event on Cyber Monday, where attendees joined three Rancho Santa Fe Foundation Donor Advised Fund families to learn about an exciting, successful and innovative crowdfunding platform for scientific research.

doubledollarsplaceholder

In December, we started a new blog series to help our donors meet the board, and we began by introducing you to Alberto Hayek, M.D., President of DRC.

This past year was monumental for DRC, and 2017 is already off to a great start with the launch of a new research project, Determining How Other Cells (Non-Beta) In The Pancreas Affect Diabetes by Jeffrey D. Serrill, Ph.D. of City of Hope, Los Angeles, California. We’re looking forward to seeing what the year holds as we fund research projects that will bring us closer to preventing, treating and curing T1D.

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ETH Researchers T1D

New Weapon Against Diabetes

Original article published by ETH Zurich on December 1, 2016. Click here to read the original article.

Researchers have used the simplest approach yet to produce artificial beta cells from human kidney cells. Like their natural model, the artificial cells act as both sugar sensors and insulin producers.

Researchers led by ETH Professor Martin Fussenegger at the Department of Biosystems Science and Engineering (D-BSSE) in Basel have produced artificial beta cells using a straightforward engineering approach. These pancreatic cells can do everything that natural ones do: they measure the glucose concentration in the blood and produce enough insulin to effectively lower the blood sugar level. The ETH researchers presented their development in the latest edition of the journal Science.

Previous approaches were based on stem cells, which the scientists allowed to mature into beta cells either by adding growth factors or by incorporating complex genetic networks.

For their new approach, the ETH researchers used a cell line based on human kidney cells, HEK cells. The researchers used the natural glucose transport proteins and potassium channels in the membrane of the HEK cells. They enhanced these with a voltage-dependent calcium channel and a gene for the production of insulin and GLP-1, a hormone involved in the regulation of the blood sugar level.

Voltage switch causes insulin production

In the artificial beta cells, the HEK cells’ natural glucose transport protein carries glucose from the bloodstream into the cell’s interior. When the blood sugar level exceeds a certain threshold, the potassium channels close. This flips the voltage distribution at the membrane, causing the calcium channels to open. As calcium flows in, it triggers the HEK cells’ built-in signalling cascade, leading to the production and secretion of insulin or GLP-1.

The initial tests of the artificial beta cells in diabetic mice revealed the cells to be extremely effective: “They worked better and for longer than any solution achieved anywhere in the world so far,” says Fussenegger. When implanted into diabetic mice, the modified HEK cells worked reliably for three weeks, producing sufficient quantities of the messengers that regulate blood sugar level.

Helpful modelling

In developing the artificial cells, the researchers had the help of a computer model created by researchers working under Jörg Stelling, another professor in ETH Zurich’s Department of Biosystems Science and Engineering (D-BSSE). The model allows predictions to be made of cell behaviour, which can be verified experimentally. “The data from the experiments and the values calculated using the models were almost identical,” says Fussenegger.

He and his group have been working on biotechnology-based solutions for diabetes therapy for a long time. Several months ago, they unveiled beta cells that had been grown from stem cells from a person’s fatty tissue. This technique is expensive, however, since the beta cells have to be produced individually for each patient. The new solution would be cheaper, as the system is suitable for all diabetics.

Market-readiness is a long way off

It remains uncertain, though, when these artificial beta cells will reach the market. They first have to undergo various clinical trials before they can be used in humans. Trials of this kind are expensive and often last several years. “If our cells clear all the hurdles, they could reach the market in 10 years,” the ETH professor estimates.

Diabetes is becoming the modern-day scourge of humanity. The International Diabetes Federation estimates that more than 640 million people worldwide will suffer from diabetes by 2040. Half a million people are affected in Switzerland today, with 40,000 of them suffering from type 1 diabetes, the form in which the body’s immune system completely destroys the insulin-producing beta cells.
[su_button url=”https://www.ethz.ch/en/news-and-events/eth-news/news/2016/12/artificial-beta-cells.html?elqTrackId=3118751de0d340b8bf7c42cba3a3a7d2&elq=3ba510d3772545b28e0cfdf8c559795e&elqaid=17762&elqat=1&elqCampaignId=10602″ target=”blank” style=”flat” background=”#64b243″ size=”6″ center=”yes” radius=”5″ icon=”icon: angle-right”]Continue Reading[/su_button]

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alberto hayek

Meet the DRC Board: Alberto Hayek, M.D.

At the Diabetes Research Connection, our passion is working together with the scientific community to find a way to treat, cure and prevent type 1 diabetes, and our board is dedicated to helping achieve our vision.

2016 has been a monumental year for us, as we’ve raised more money than ever before for early-career scientists’ T1D research. One of our core values is to build a strong connection between the board and our supporters. Thus, we’ve interviewed members of our board to find out more about the impact T1D has had on their lives, why they choose to work with DRC and much more.

First up, get to know one of DRC’s founders, Dr. Alberto Hayek.

Alberto Hayek, M.D., President of DRC

Dr. Hayek is the Scientific Director at San Diego’s Scripps Whittier Institute for Diabetes and Professor Emeritus of Pediatrics at UCSD. He is a world-renowned diabetes expert in pancreatic islet research and experimental cell replacement therapies for T1D.

We asked Dr. Hayek a few questions to help our donors get to know him better.

How have you been affected by T1D?

Taking care of children with T1D gave me a first-hand glimpse of the struggles this disease causes for patients and their families.

What is the most rewarding part of serving on the DRC board for you personally?

The opportunity to provide funding for junior investigators in T1D as they take their first steps for independent thinking in research and care has been tremendously rewarding.

What is your favorite holiday tradition, related to T1D or not?

I spend a day during Christmas with my grandchildren, ages 3 and 6, making sandwiches for homeless people in San Diego.

Once again, we want to extend a heartfelt thank you to all our donors for helping to make 2016 such a successful year for DRC, and helping to fund innovative T1D research. We’re looking forward to all that 2017 will bring, and we’re hopeful that a year from now we’ll be even closer to eradicating T1D.

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diabetes research

Economic 3D-Printing Approach for Transplantation of Human Stem Cell-Derived β-Like Cells

Original article published by IOP Science on December 1, 2016. Click here to read the original article.

Abstract

Transplantation of human pluripotent stem cells (hPSC) differentiated into insulin-producing βcells is a regenerative medicine approach being investigated for diabetes cell replacement therapy. This report presents a multifaceted transplantation strategy that combines differentiation into stem cell-derived β (SC-β) cells with 3D printing. By modulating the parameters of a low-cost 3D printer, we created a macroporous device composed of polylactic acid (PLA) that houses SC-β cell clusters within a degradable fibrin gel. Using finite element modeling of cellular oxygen diffusion-consumption and an in vitro culture system that allows for culture of devices at physiological oxygen levels, we identified cluster sizes that avoid severe hypoxia within 3D-printed devices and developed a microwell-based technique for resizing clusters within this range. Upon transplantation into mice, SC-β cell-embedded 3D-printed devices function for 12 weeks, are retrievable, and maintain structural integrity. Here, we demonstrate a novel 3D-printing approach that advances the use of differentiated hPSC for regenerative medicine applications and serves as a platform for future transplantation strategies.

[su_button url=”http://iopscience.iop.org/article/10.1088/1758-5090/9/1/015002/meta?elqTrackId=96062d779f46499eb7cc18d9ab30d665&elq=3d599e01edda49df92afa531a8a717ae&elqaid=17717&elqat=1&elqCampaignId=10609″ target=”blank” style=”flat” background=”#64b243″ size=”6″ center=”yes” radius=”5″ icon=”icon: angle-right”]Continue Reading[/su_button]

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holiday travel

Holiday Travel Tips for Those With T1D

The holiday season is in full swing, and many of us will be traveling this month to visit friends, family and loved ones. For those with type 1 diabetes (T1D), though, holiday travels may require a bit more planning. Below we’ve outlined a few things to keep in mind when planning a trip if you or a loved one you are traveling with has T1D. Following these tips will help your travels go smoothly, ensuring a joyous time for all.

Packing Your Medication and Supplies

Whether you’re traveling across the state for a long weekend or across the country for a full week, you’ll need to be strategic when packing your medication and other supplies. Make sure you bring enough of your medication so you’re prepared for any situation that may arise; many find that packing twice as much as they think they’ll need is a safe option. If you’ll be checking any luggage, keep your medicine and anything else you will need in your carry-on, so that you have it if your bags get lost.

In your carry-on bag, make sure you have:

  • Insulin and syringes
  • Blood-testing supplies and extra batteries
  • Any other medications you may need
  • An ID, including something that identifies you as having T1D
  • A small snack and candy or some form of sugar to treat hypoglycemia

As you’re packing, be thinking of where you’ll store your supplies upon arrival. In particular, don’t store your insulin somewhere very hot or very cold, such as the trunk of a car.

Preparing for an Emergency if You’re Abroad

Anyone traveling to another country should have a plan in place in case of a medical emergency, but this is especially important for those with T1D.

If you would like to get a list of English-speaking doctors at your destination before you leave, we suggest contacting the International Association for Medical Assistance to Travelers. If something happens while you’re abroad and you’re unsure of where to go, contact your local embassy for assistance.

Of course, preventing an emergency is better than preparing for one. This goes without saying, but check your blood glucose levels frequently, and be mindful of crossing time zones when you’re planning the timing of your injections.

Keep Your Medical ID With You

It’s always a good idea to be wearing a medical ID identifying you as someone with T1D, but this can become even more important when traveling. In the event of an emergency, your ID will let first responders, doctors and nurses know that you have T1D and provide information about how you manage it, as well as information about allergies and other pieces of your medical history.

Traditionally, these medical IDs are worn as a bracelet or necklace, and usually consist of a piece of metal with information etched into it. However, modern technology has to lead to more detailed medical IDs with QR codes, URLs and more that can help emergency responders and medical personnel access all your necessary health records.

For more tips and insights for living with type 1 diabetes, subscribe to our newsletter.

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insulin

“Artificial Pancreas” Is Approved

Original article published by The JAMA Network on October 4, 2016. Click here to read the original article.

A new device that automatically monitors blood glucose levels and adjusts insulin levels has received FDA approval. The device, manufactured by Dublin-based Medtronic PLC, is the first such system to gain the agency’s blessing.

The new MiniMed 670G hybrid closed-loop system is intended for people aged 14 years or older who have type 1 diabetes. Because it operates with a smart algorithm that learns an individual’s insulin needs and delivers appropriate basal doses 24 hours a day, little user input is required. Patients who use the system will only have to enter their mealtime carbohydrates, accept bolus correction recommendations, and periodically calibrate the sensor.

[su_button url=”http://jamanetwork.com/journals/jama/article-abstract/2584035″ target=”blank” style=”flat” background=”#64b243″ size=”6″ center=”yes” radius=”5″ icon=”icon: angle-right”]Continue Reading[/su_button]

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Diabetes Supplies - Bottles

Imbalance of Bacteriome Profiles Within the Finnish Diabetes Prediction and Prevention Study

Original article published by Wiley Online Library on August 22, 2016. Click here to read the original article.

Abstract

Background

We set out to explore associations between the stool bacteriome profiles and early-onset islet autoimmunity, taking into account the interactions with the virus component of the microbiome.

Methods

Serial stool samples were longitudinally collected from 18 infants and toddlers with early-onset islet autoimmunity (median age 17.4 months) followed by type 1 diabetes, and 18 tightly matched controls from the Finnish Diabetes Prediction and Prevention (DIPP) cohort. Three stool samples were analyzed, taken 3, 6, and 9 months before the first detection of serum autoantibodies in the case child. The risk of islet autoimmunity was evaluated in relation to the composition of the bacteriome 16S rDNA profiles assessed by mass sequencing, and to the composition of DNA and RNA viromes.

Results

Four operational taxonomic units were significantly less abundant in children who later on developed islet autoimmunity as compared to controls—most markedly the species of Bacteroides vulgatus and Bifidobacterium bifidum. The alpha or beta diversity, or the taxonomic levels of bacterial phyla, classes or genera, showed no differences between cases and controls. A correlation analysis suggested a possible relation between CrAssphage signals and quantities of Bacteroides dorei. No apparent associations were seen between development of islet autoimmunity and sequences of yet unknown origin.

Conclusions

The results confirm previous findings that an imbalance within the prevalent Bacteroidesgenus is associated with islet autoimmunity. The detected quantitative relation of the novel “orphan” bacteriophage CrAssphage with a prevalent species of the Bacteroides genus may exemplify possible modifiers of the bacteriome.

[su_button url=”http://onlinelibrary.wiley.com/doi/10.1111/pedi.12468/full” target=”blank” style=”flat” background=”#64b243″ size=”6″ center=”yes” radius=”5″ icon=”icon: angle-right”]Continue Reading[/su_button]

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pumpkin mashed potatoes

A Diabetes-Friendly Thanksgiving

Food-heavy holidays, such as Thanksgiving, can be particularly hard for those with type 1 diabetes. Between carb-heavy foods, meals served at odd times to accommodate everyone’s schedules and perhaps even multiple meals with different sides of the family or groups of friends, keeping your blood sugar in check on Thanksgiving day is no easy task.

However, with careful planning and some support from your family and friends, enjoying Thanksgiving doesn’t have to be difficult!

As you’re celebrating, keep the following in mind:

  • Keep fat content of the foods you are eating in mind. For example, make your mashed potatoes with low-fat milk and margarine instead of butter.
  • Choose white meat turkey over dark meat, and skip the skin.
  • Opt for steamed vegetables over casseroles. For example, serve seasoned steamed green beans with salt, pepper and garlic powder instead of green bean casserole.

Thanksgiving Recipes for Diabetes

If you’re responsible for preparing a dish for a potluck or an entire Thanksgiving meal, consider these T1D-friendly takes on traditional Thanksgiving favorites.

Pumpkin Mashed Potatoes

Recipe from Diabetic Living Online.

The addition of pumpkin makes for a flavorful, low-calorie twist on traditional mashed potatoes.

[su_spoiler title=”View recipe.”]

Makes 4 servings.

1 pound medium baking potatoes, peeled and quartered

2 cloves garlic, peeled

1 cup canned pumpkin

2 tablespoons reduced-fat cream cheese (Neufchatel)

1 tablespoon butter or tub-style vegetable oil spread

1/8 teaspoon ground sage

1/4 cup fat-free milk

1.In a covered large saucepan, cook potatoes and garlic in enough boiling water to cover for 20 to 25 minutes or until potatoes are tender; drain.

2. Mash with a potato masher or beat with an electric mixer on low speed until nearly smooth.

3. Beat in canned pumpkin, cream cheese, butter, ground sage, 1/4 teaspoon salt, and 1/4 teaspoon ground black pepper.

4. Gradually add milk, beating until light and fluffy.

5. Return to saucepan; heat through.

Nutrition (per serving): 159 calories, 5 g fat, 3 g saturated fat, 13 mg cholesterol, 206 mg sodium, 26 g carbohydrates, 4 g fiber, 4 g sugars, 4 g protein

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Sweet Raisin-Apple Strudel

Recipe from Prevention

Whole-wheat phyllo dough makes this dessert a slightly healthier replacement for apple pie.

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Makes 12 servings.

2 granny smith or golden delicious apples, peeled, cored, and thinly sliced (about 3 c)

1/4 cup packed light brown sugar

2 tablespoons golden raisins

1/2 teaspoon ground cinnamon

1/4 teaspoon ground nutmeg

1/3 cup plain dry bread crumbs

1/4 cup granulated sugar

12 sheets (17″ x 11″ each) frozen whole wheat phyllo dough, thawed

1/2 cup apricot all-fruit preserves, warmed

1 tablespoon confectioners’ sugar

1. Preheat the oven to 400°F. Line a large baking sheet with parchment paper.

2. Mix the apples, brown sugar, raisins, cinnamon, and nutmeg in a large bowl.

3. Mix the breadcrumbs and granulated sugar in a small bowl.

4. Place the phyllo on a dry kitchen counter and cover with plastic wrap and a damp towel to keep it from drying out. Remove 1 sheet, spread it flat, and mist with butter-flavored cooking spray. Sprinkle with 1 scant tablespoon of the crumb mixture. Repeat layering to use 4 more of the remaining phyllo sheets and about half of the crumb mixture. Top with 1 phyllo sheet and mist with the cooking spray.

5. Spread with 1/4 cup of the preserves to within 1″ of the edges. Spoon half of the apple mixture over the preserves. Fold 1″ of each long edge over the apple mixture. Starting with the short edge, roll up as tightly as possible. Gently place the strudel, seam side down, on the prepared baking sheet. Mist the top with cooking spray.

6. Repeat to make a second strudel.

7. Using a sharp knife, make several slashes in the top of each strudel.

8. Bake for 15 minutes, or until crisp and golden brown. Sprinkle with the confectioners’ sugar. Serve warm.

Nutrition (per serving) 153 calories, 1 g fat, 0 g saturated fat, 2 g protein, 34 g carbohydrates, 18 g sugar, 1 g fiber, 121 mg sodium

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world diabetes day

How to Honor National Diabetes Month

Diabetes affects more than 29 million Americans and is the 7th leading cause of death in the US today. While Diabetes Research Connection fights to find a cure for type 1 diabetes every month, we give an extra push during the month of November for National Diabetes Month. There are many ways you can contribute during National Diabetes Month, including our Double Your Dollars campaign, shopping with AmazonSmile, volunteering at a hospital or research center or participating in a walk/run benefiting diabetes. Read below for more details on how you can get involved.

Make Your Donation Count Twice As Much With Double Your Dollars

In honor of National Diabetes Month, DRC is matching every dollar donated to the General Fund (up to $50,000) between now and November 30 through our Double Your Dollars campaign. It is the perfect time to make a difference in the T1D community by donating to our campaign and making your charitable act go twice as far.

Every donation helps early-career scientists launch their ideas and allows 100% of funds directed for T1D research to go directly to the researcher’s laboratory. Donations are critical for us to operate our innovative platform, even though DRC’s operating costs are kept less than 10% of gross revenue.

Make a Difference While Shopping on Amazon

November is the month where most of us start our holiday shopping- the excitement of the good deals of Black Friday and Cyber Monday are almost too much to bear. If the crowds and late hours of Black Friday intimidate and overwhelm you and Cyber Monday is more your speed, try using AmazonSmile to accommodate all your holiday shopping needs. AmazonSmile is Amazon’s nonprofit charitable support arm and allows the shopper to choose from a variety of charities who will benefit monetarily from their purchases, without any additional cost to the shopper.

To honor National Diabetes Month, you can do your holiday shopping through AmazonSmile and select Diabetes Research Connection as your charity of choice so that a portion of your purchase goes to finding a cure for those with T1D. Visit smile.amazon.com to get started.

Participate in a Walk or Run

A great way to get involved with the fight to find a cure for T1D and honor National Diabetes Month is to participate in a walk/run benefiting diabetes. Not only would it be benefitting a great cause, but doing a walk/run is a great way to be active with a big group of people. There are many options available depending on what area you live, so it helps to do some research to find one that suits your fitness level needs.

Volunteer at a Hospital or Research Center

It’s very easy to find places that need volunteers, such as hospitals or research centers. Not only is it a good time of year to donate your time because of the holiday giving season, but also because of National Diabetes Month- you can opt for a research center or a hospital that specializes in T1D. This is the perfect way to give back for those who can’t donate money.

For more information on how you can get involved in the fight to find a cure for T1D, and to receive frequent updates about DRC, sign up for our newsletter!

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OUR PROJECTS

See our approved research projects and campaigns.

Role of the integrated stress response in type 1 diabetes pathogenesis
In individuals with type 1 diabetes (T1D), the insulin-producing beta cells are spontaneously destroyed by their own immune system. The trigger that provokes the immune system to destroy the beta cells is unknown. However, accumulating evidence suggest that signals are perhaps first sent out by the stressed beta cells that eventually attracts the immune cells. Stressed cells adapt different stress mitigation systems as an adaptive response. However, when these adaptive responses go awry, it results in cell death. One of the stress response mechanisms, namely the integrated stress response (ISR) is activated under a variety of stressful stimuli to promote cell survival. However, when ISR is chronically activated, it can be damaging to the cells and can lead to cell death. The role of the ISR in the context of T1D is unknown. Therefore, in this DRC funded study, we propose to study the ISR in the beta cells to determine its role in propagating T1D.
Wearable Skin Fluorescence Imaging Patch for the Detection of Blood Glucose Level on an Engineered Skin Platform
zhang
A Potential Second Cure for T1D by Re-Educating the Patient’s Immune System
L Ferreira
Validating the Hypothesis to Cure T1D by Eliminating the Rejection of Cells From Another Person by Farming Beta Cells From a Patient’s Own Stem Cells
Han Zhu
Taming a Particularly Lethal Category of Cells May Reduce/Eliminate the Onset of T1D
JRDwyer 2022 Lab 1
Can the Inhibition of One Specific Body Gene Prevent Type 1 Diabetes?
Melanie
Is Cholesterol Exacerbating T1D by Reducing the Functionality and Regeneration Ability of Residual Beta Cells?
Regeneration Ability of Residual Beta Cells
A Call to Question… Is T1D Caused by Dysfunctionality of Two Pancreatic Cells (β and α)?
Xin Tong
Novel therapy initiative with potential path to preventing T1D by targeting TWO components of T1D development (autoimmune response and beta-cell survival)
flavia pecanha